Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 600635..601434 Replicon chromosome
Accession NZ_CP073719
Organism Escherichia coli strain CX12

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag J6O05_RS02975 Protein ID WP_000347267.1
Coordinates 600635..601099 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID C3ST72
Locus tag J6O05_RS02980 Protein ID WP_001302819.1
Coordinates 601099..601434 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O05_RS02945 (596179) 596179..596958 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
J6O05_RS02950 (596969) 596969..597143 - 175 Protein_578 PTS sugar transporter subunit IIB -
J6O05_RS02955 (597172) 597172..597869 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
J6O05_RS02960 (597884) 597884..598219 - 336 Protein_580 PTS N-acetylgalactosamine transporter subunit IIB -
J6O05_RS02965 (598242) 598242..599522 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
J6O05_RS02970 (599771) 599771..600580 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
J6O05_RS02975 (600635) 600635..601099 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
J6O05_RS02980 (601099) 601099..601434 - 336 WP_001302819.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
J6O05_RS02985 (601583) 601583..603154 - 1572 WP_057107993.1 galactarate dehydratase -
J6O05_RS02990 (603529) 603529..604863 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
J6O05_RS02995 (604879) 604879..605649 + 771 WP_001559981.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T200106 WP_000347267.1 NZ_CP073719:c601099-600635 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T200106 NZ_CP097711:995762-996169 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12388.97 Da        Isoelectric Point: 4.8616

>AT200106 WP_001302819.1 NZ_CP073719:c601434-601099 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDTDIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT200106 NZ_CP097711:995515-995781 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4


Antitoxin

Source ID Structure

References