Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 186623..186845 Replicon chromosome
Accession NZ_CP073719
Organism Escherichia coli strain CX12

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag J6O05_RS00890 Protein ID WP_001295224.1
Coordinates 186738..186845 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 186623..186681 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O05_RS00865 182011..182994 + 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
J6O05_RS00870 182991..183995 + 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
J6O05_RS00875 184025..185296 - 1272 WP_001295225.1 aromatic amino acid transport family protein -
J6O05_RS00880 185772..185879 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
J6O05_RS00885 186255..186362 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- 186623..186681 - 59 - - Antitoxin
J6O05_RS00890 186738..186845 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
J6O05_RS00895 187221..187328 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
J6O05_RS00900 187415..189094 - 1680 WP_000191613.1 cellulose biosynthesis protein BcsG -
J6O05_RS00905 189091..189282 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
J6O05_RS00910 189279..190301 - 1023 Protein_179 cellulose biosynthesis protein BcsE -
J6O05_RS00915 190357..191054 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
J6O05_RS00920 191071..191193 + 123 Protein_181 cellulose biosynthesis protein BcsR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-35)


Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T200101 WP_001295224.1 NZ_CP073719:186738-186845 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T200101 NZ_CP097710:4076223-4076801 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAACTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 59 bp

>AT200101 NZ_CP073719:c186681-186623 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7


Antitoxin

Download structure file

References