Detailed information of TA system TA200099

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 186140..186362
• Replicon: chromosome
• Accession: NZ_CP073719
• Organism: Escherichia coli strain CX12

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: J6O05_RS00885
• Protein ID: WP_001295224.1
• Coordinates: 186255..186362 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	186140..186197 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O05_RS00865	182011..182994	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
J6O05_RS00870	182991..183995	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
J6O05_RS00875	184025..185296	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
J6O05_RS00880	185772..185879	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	186140..186197	-	58	-	-	Antitoxin
J6O05_RS00885	186255..186362	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
J6O05_RS00890	186738..186845	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
J6O05_RS00895	187221..187328	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
J6O05_RS00900	187415..189094	-	1680	WP_000191613.1	cellulose biosynthesis protein BcsG	-
J6O05_RS00905	189091..189282	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
J6O05_RS00910	189279..190301	-	1023	Protein_179	cellulose biosynthesis protein BcsE	-
J6O05_RS00915	190357..191054	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
J6O05_RS00920	191071..191193	+	123	Protein_181	cellulose biosynthesis protein BcsR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T200099 WP_001295224.1 NZ_CP073719:186255-186362 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T200099 NZ_CP097710:2490086-2490544 [Pseudomonas aeruginosa]
ATGCAACGGCATGGCTGGACGCTGCTCTTCCACGACTGCGTGATCGAGCAGTTGCAGAAACTGCATGCGGCCGCGAGGCG
CGCGCAGGAGAATGACCCGGCGGGCTTCGAGTCCAATGCCAACGTCAAGCTCTTCCGGGCCCTGAGCCAGTTGATGTTGG
ATGTGGTGCCAGGCGATCCGGCACGCGACGAGTACCGCCAGGGCAACACCTTGGGACCTGCCCACCGCCACTGGCGAAGG
GCCAAGATCGGACGGCGGTTCCGGCTGTTCTTCCGGTACGACTCGAAGGCGAAGGTCATTGTGTACGCCTGGGTCAACGA
TGAACAGACCCTGCGGTCTTCGGGTAGCAAATCGGACCCGTATGTCGTGTTCGAGAAGATGCTCGGACGCGGGAACCCAC
CAGACGACTGGCACGCGCTGATACAGGCAAGCAAGCAGGATTGGAGCAAACTGGAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT200099 NZ_CP073719:c186197-186140 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin