Detailed information of TA system TA200096

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4057708..4057966
• Replicon: chromosome
• Accession: NZ_CP073718
• Organism: Escherichia coli strain CX08

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: J6O57_RS20115
• Protein ID: WP_000809168.1
• Coordinates: 4057814..4057966 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4057708..4057765 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O57_RS20095	4052733..4054087	+	1355	Protein_3931	fimbria/pilus outer membrane usher protein	-
J6O57_RS20100	4054100..4055059	+	960	WP_000871671.1	hypothetical protein	-
J6O57_RS20105	4055097..4055996	-	900	WP_001300855.1	transcriptional activator NhaR	-
J6O57_RS20110	4056062..4057228	-	1167	WP_057107799.1	Na+/H+ antiporter NhaA	-
-	4057708..4057765	-	58	-	-	Antitoxin
J6O57_RS20115	4057814..4057966	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
J6O57_RS20120	4058070..4059200	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
J6O57_RS20125	4059289..4061205	-	1917	WP_000516135.1	molecular chaperone DnaK	-
J6O57_RS20130	4061598..4062295	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
J6O57_RS20135	4062359..4062763	+	405	WP_000843559.1	DUF2541 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T200096 WP_000809168.1 NZ_CP073718:4057814-4057966 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T200096 NZ_CP097709:c5961664-5961386 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT200096 NZ_CP073718:c4057765-4057708 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin