Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 68309..68943 Replicon chromosome
Accession NZ_CP073718
Organism Escherichia coli strain CX08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J6O57_RS00330 Protein ID WP_057108200.1
Coordinates 68650..68943 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J6O57_RS00325 Protein ID WP_057108202.1
Coordinates 68309..68635 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6O57_RS00305 (63430) 63430..64035 - 606 Protein_59 DNA damage-inducible protein D -
J6O57_RS00315 (64804) 64804..67401 - 2598 WP_223566610.1 DEAD/DEAH box helicase -
J6O57_RS00320 (67391) 67391..68239 - 849 WP_057108201.1 SAVED domain-containing protein -
J6O57_RS00325 (68309) 68309..68635 - 327 WP_057108202.1 HigA family addiction module antitoxin Antitoxin
J6O57_RS00330 (68650) 68650..68943 - 294 WP_057108200.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J6O57_RS00335 (69073) 69073..70284 - 1212 WP_223566612.1 site-specific integrase -
J6O57_RS00340 (70456) 70456..71319 - 864 WP_000621340.1 YicC/YloC family endoribonuclease -
J6O57_RS00345 (71446) 71446..72162 + 717 WP_001247093.1 ribonuclease PH -
J6O57_RS00350 (72227) 72227..72868 + 642 WP_000806161.1 orotate phosphoribosyltransferase -
J6O57_RS00355 (72905) 72905..73501 - 597 WP_000818601.1 nucleoid occlusion factor SlmA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11470.89 Da        Isoelectric Point: 5.1406

>T200068 WP_057108200.1 NZ_CP073718:c68943-68650 [Escherichia coli]
MAVEFRDTWLEAFYEDDQNHRRIPSTIEGALFRKLEILDAATQESDLRIPPGNRFEHLEGNMAGWCSIRVNKQYRLIFRW
IDGVAQDTYLDPHVYRG

Download         Length: 294 bp

>T200068 NZ_CP097697:1977121-1977223 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12363.29 Da        Isoelectric Point: 8.8778

>AT200068 WP_057108202.1 NZ_CP073718:c68635-68309 [Escherichia coli]
MRNTKRRPVTVGQMLVTEFLEPMNIEINELAEAMGVHRNTLSRIVHDKGALTAPMSIKLAAALGNTPEFWLNIQHSVELW
DVRHRAFEQEAKNVKRVTPHLENREAVI

Download         Length: 327 bp

>AT200068 NZ_CP097697:c1977230-1977085 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References