Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4476984..4477738 Replicon chromosome
Accession NZ_CP073715
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain 2020LSAL11867

Toxin (Protein)


Gene name higB Uniprot ID A0A8F2V0H8
Locus tag KCG42_RS21550 Protein ID WP_024792370.1
Coordinates 4476984..4477295 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KCG42_RS21555 Protein ID WP_031609809.1
Coordinates 4477292..4477738 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG42_RS21520 (4472642) 4472642..4473544 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
KCG42_RS21525 (4473541) 4473541..4474176 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
KCG42_RS21530 (4474173) 4474173..4475102 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
KCG42_RS21535 (4475149) 4475149..4475439 - 291 WP_213146992.1 helix-turn-helix domain-containing protein -
KCG42_RS21540 (4475440) 4475440..4475751 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
KCG42_RS21545 (4475969) 4475969..4476898 + 930 WP_051124513.1 alpha/beta hydrolase -
KCG42_RS21550 (4476984) 4476984..4477295 + 312 WP_024792370.1 type II toxin-antitoxin system HigB family toxin Toxin
KCG42_RS21555 (4477292) 4477292..4477738 + 447 WP_031609809.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
KCG42_RS21560 (4477753) 4477753..4478694 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
KCG42_RS21565 (4478739) 4478739..4479176 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
KCG42_RS21570 (4479173) 4479173..4480045 - 873 WP_000921423.1 virulence factor BrkB family protein -
KCG42_RS21575 (4480039) 4480039..4480638 - 600 WP_000965698.1 glucose-1-phosphatase -
KCG42_RS21580 (4480829) 4480829..4481632 - 804 WP_021000967.1 DeoR/GlpR family DNA-binding transcription regulator -
KCG42_RS21585 (4481666) 4481666..4482562 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12466.42 Da        Isoelectric Point: 9.5334

>T200067 WP_024792370.1 NZ_CP073715:4476984-4477295 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
VHVISRKPFNEAMLMYPNHELAFTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T200067 NZ_CP097697:883291-883701 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16721.00 Da        Isoelectric Point: 6.0016

>AT200067 WP_031609809.1 NZ_CP073715:4477292-4477738 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEETPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT200067 NZ_CP097697:883044-883310 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References