Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
| Location | 4475149..4475751 | Replicon | chromosome |
| Accession | NZ_CP073715 | ||
| Organism | Salmonella enterica subsp. enterica serovar Bovismorbificans strain 2020LSAL11867 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | M7S4R6 |
| Locus tag | KCG42_RS21540 | Protein ID | WP_001159635.1 |
| Coordinates | 4475440..4475751 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KCG42_RS21535 | Protein ID | WP_213146992.1 |
| Coordinates | 4475149..4475439 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KCG42_RS21520 (4472642) | 4472642..4473544 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| KCG42_RS21525 (4473541) | 4473541..4474176 | + | 636 | WP_000829028.1 | formate dehydrogenase cytochrome b556 subunit | - |
| KCG42_RS21530 (4474173) | 4474173..4475102 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| KCG42_RS21535 (4475149) | 4475149..4475439 | - | 291 | WP_213146992.1 | helix-turn-helix domain-containing protein | Antitoxin |
| KCG42_RS21540 (4475440) | 4475440..4475751 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | Toxin |
| KCG42_RS21545 (4475969) | 4475969..4476898 | + | 930 | WP_051124513.1 | alpha/beta hydrolase | - |
| KCG42_RS21550 (4476984) | 4476984..4477295 | + | 312 | WP_024792370.1 | type II toxin-antitoxin system HigB family toxin | - |
| KCG42_RS21555 (4477292) | 4477292..4477738 | + | 447 | WP_031609809.1 | type II toxin-antitoxin system HigA family antitoxin | - |
| KCG42_RS21560 (4477753) | 4477753..4478694 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| KCG42_RS21565 (4478739) | 4478739..4479176 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| KCG42_RS21570 (4479173) | 4479173..4480045 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| KCG42_RS21575 (4480039) | 4480039..4480638 | - | 600 | WP_000965698.1 | glucose-1-phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12340.30 Da Isoelectric Point: 9.4460
>T200066 WP_001159635.1 NZ_CP073715:c4475751-4475440 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
Download Length: 312 bp
>T200066 NZ_CP097697:745609-746094 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10928.57 Da Isoelectric Point: 10.3460
>AT200066 WP_213146992.1 NZ_CP073715:c4475439-4475149 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
LAIANDPRNVIQALRY
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
LAIANDPRNVIQALRY
Download Length: 291 bp
>AT200066 NZ_CP097697:745319-745612 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|