Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 861589..862226 Replicon chromosome
Accession NZ_CP073697
Organism Edaphobacter flagellatus strain HZ411

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KFE13_RS03510 Protein ID WP_260705797.1
Coordinates 861900..862226 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KFE13_RS03505 Protein ID WP_260705796.1
Coordinates 861589..861903 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFE13_RS03475 856708..859191 - 2484 WP_260705792.1 DUF87 domain-containing protein -
KFE13_RS03480 859191..859493 - 303 WP_260705793.1 VirB3 family type IV secretion system protein -
KFE13_RS03485 859542..859877 - 336 WP_260705794.1 TrbC/VirB2 family protein -
KFE13_RS03490 859998..860771 - 774 WP_260706897.1 LysR substrate-binding domain-containing protein -
KFE13_RS03495 860658..861044 + 387 WP_260707012.1 hypothetical protein -
KFE13_RS03500 861223..861504 + 282 WP_260705795.1 helix-turn-helix domain-containing protein -
KFE13_RS03505 861589..861903 - 315 WP_260705796.1 helix-turn-helix transcriptional regulator Antitoxin
KFE13_RS03510 861900..862226 - 327 WP_260705797.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFE13_RS03515 862319..862903 - 585 WP_260706898.1 site-specific integrase -
KFE13_RS03520 864057..865022 + 966 WP_260705798.1 sugar phosphate isomerase/epimerase -
KFE13_RS03525 865161..865427 + 267 WP_260705799.1 hypothetical protein -
KFE13_RS03530 865483..866319 - 837 WP_260705800.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 805941..883432 77491


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-86)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12393.65 Da        Isoelectric Point: 10.4058

>T200030 WP_260705797.1 NZ_CP073697:c862226-861900 [Edaphobacter flagellatus]
MASWLVEFLDEGVKASLDALPLDIRASFQRIVELIQAHGLERVREPYVKHLEGPLWEMRMKGKSGIARACYVTAVGKRIV
VVHVFVKKTQKTPRRELELALRRAKEVE

Download         Length: 327 bp

>T200030 NZ_CP097689:50854-51165 [Klebsiella pneumoniae]
ATGCACATTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11621.28 Da        Isoelectric Point: 10.4623

>AT200030 WP_260705796.1 NZ_CP073697:c861903-861589 [Edaphobacter flagellatus]
MKRKFIPAEESFREWKKDPSFVAAYDALENEFALASALIEARSKADMTQEEVAAAMGTTQAVVARLESGKVLPSTRTLER
FARATRSRLRISFESNQPALAAKR

Download         Length: 315 bp

>AT200030 NZ_CP097689:51162-51581 [Klebsiella pneumoniae]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References