Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1405281..1405874 Replicon chromosome
Accession NZ_CP073677
Organism Cupriavidus sp. KK10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KB879_RS06955 Protein ID WP_041228359.1
Coordinates 1405596..1405874 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KB879_RS06950 Protein ID WP_013956365.1
Coordinates 1405281..1405583 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB879_RS06925 (KB879_06925) 1401101..1403548 + 2448 WP_211980961.1 phenylalanine--tRNA ligase subunit beta -
KB879_RS06930 (KB879_06930) 1403650..1404060 + 411 WP_153955928.1 integration host factor subunit alpha -
KB879_RS06935 (KB879_06935) 1404177..1404602 + 426 WP_013956331.1 MerR family transcriptional regulator -
KB879_RS06945 (KB879_06945) 1404895..1405188 + 294 WP_238553062.1 hypothetical protein -
KB879_RS06950 (KB879_06950) 1405281..1405583 - 303 WP_013956365.1 HigA family addiction module antitoxin Antitoxin
KB879_RS06955 (KB879_06955) 1405596..1405874 - 279 WP_041228359.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KB879_RS06960 (KB879_06960) 1406189..1406695 - 507 WP_211980962.1 cupin domain-containing protein -
KB879_RS06965 (KB879_06965) 1406739..1406999 - 261 WP_035817461.1 hypothetical protein -
KB879_RS06970 (KB879_06970) 1407271..1407612 + 342 WP_235205703.1 hypothetical protein -
KB879_RS06975 (KB879_06975) 1407653..1407886 + 234 WP_035817458.1 hypothetical protein -
KB879_RS06980 (KB879_06980) 1407978..1408166 + 189 WP_018310329.1 hypothetical protein -
KB879_RS06985 (KB879_06985) 1408267..1408626 + 360 WP_013956372.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(24-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10408.91 Da        Isoelectric Point: 8.3165

>T200020 WP_041228359.1 NZ_CP073677:c1405874-1405596 [Cupriavidus sp. KK10]
MITSFNCRDTALLFAGTRIARFVNIESVAMRKLQQLHAAGDLSFLRVPPGNRLEALQGHRAGQHSIRINDQWRICFCFAN
GHATDVEIVDYH

Download         Length: 279 bp

>T200020 NZ_CP097688:388084-388431 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11067.78 Da        Isoelectric Point: 6.4670

>AT200020 WP_013956365.1 NZ_CP073677:c1405583-1405281 [Cupriavidus sp. KK10]
MAREVPLATPGEILQLDWLDPLGISQYALAKAIDVPPRRINEIVKGGRAITADTAVRLGAFFGTDPQSWMNLQTHFDTEM
AKEKIGEKKLESIRQHAVLA

Download         Length: 303 bp

>AT200020 NZ_CP097688:388431-388730 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References