Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2123209..2123824 Replicon chromosome
Accession NZ_CP073638
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KEC55_RS25880 Protein ID WP_282507955.1
Coordinates 2123209..2123550 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KEC55_RS25885 Protein ID WP_282507956.1
Coordinates 2123537..2123824 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS25850 (KEC55_25795) 2119071..2119490 - 420 WP_282507949.1 secondary thiamine-phosphate synthase enzyme YjbQ -
KEC55_RS25855 (KEC55_25800) 2119501..2119827 - 327 WP_282507950.1 thioredoxin family protein -
KEC55_RS25860 (KEC55_25805) 2120105..2120815 + 711 WP_282507951.1 flavin reductase family protein -
KEC55_RS25865 (KEC55_25810) 2120869..2121201 + 333 WP_282507952.1 DUF2322 family protein -
KEC55_RS25870 (KEC55_25815) 2121276..2122142 + 867 WP_282507953.1 PASTA domain-containing protein -
KEC55_RS25875 (KEC55_25820) 2122352..2122984 + 633 WP_282507954.1 LysE family translocator -
KEC55_RS25880 (KEC55_25825) 2123209..2123550 + 342 WP_282507955.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEC55_RS25885 (KEC55_25830) 2123537..2123824 + 288 WP_282507956.1 helix-turn-helix transcriptional regulator Antitoxin
KEC55_RS25890 (KEC55_25835) 2123867..2124592 - 726 WP_282507957.1 YebB family permuted papain-like enzyme -
KEC55_RS25895 (KEC55_25840) 2124740..2125309 - 570 WP_282507958.1 hypothetical protein -
KEC55_RS25900 (KEC55_25845) 2125546..2126004 - 459 WP_012365188.1 Lrp/AsnC family transcriptional regulator -
KEC55_RS25905 (KEC55_25850) 2126130..2126864 + 735 WP_059696142.1 AzlC family ABC transporter permease -
KEC55_RS25910 (KEC55_25855) 2126857..2127165 + 309 WP_282507959.1 AzlD family protein -
KEC55_RS25915 (KEC55_25860) 2127340..2128119 + 780 WP_282507960.1 5'/3'-nucleotidase SurE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12970.26 Da        Isoelectric Point: 10.7867

>T199975 WP_282507955.1 NZ_CP073638:2123209-2123550 [Burkholderia cepacia]
MQTVAYEIRFFSAQVEAGVFALPKTLTARFFALADRMERCGPNLGEPHTKPIGEGLYEMRLKGLEGIARVFYCAVVNRRI
VMLHSFVKKTQRTPHKELATARRRLKEVRYGNL

Download         Length: 342 bp

>T199975 NZ_CP097675:742487-742972 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10434.07 Da        Isoelectric Point: 10.2748

>AT199975 WP_282507956.1 NZ_CP073638:2123537-2123824 [Burkholderia cepacia]
MATYKALRERALADPEVRAEYERLNREEFALLDAMLAARRAAGLSQAEVAERMGTKAPAVTRLERALATGRHSPSIDTLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT199975 NZ_CP097675:742197-742490 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References