Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1975479..1976058 Replicon chromosome
Accession NZ_CP073633
Organism Methylorubrum extorquens strain ATCC 55366

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KEC54_RS09460 Protein ID WP_056111697.1
Coordinates 1975479..1975760 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KEC54_RS09465 Protein ID WP_056111693.1
Coordinates 1975774..1976058 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC54_RS09445 (KEC54_09315) 1970886..1971407 + 522 WP_003602674.1 translation initiation factor IF-3 -
KEC54_RS09450 (KEC54_09320) 1971599..1973935 - 2337 WP_056111703.1 glycogen debranching N-terminal domain-containing protein -
KEC54_RS09455 (KEC54_09325) 1974094..1975227 - 1134 WP_056111700.1 glycosyltransferase family 4 protein -
KEC54_RS09460 (KEC54_09330) 1975479..1975760 + 282 WP_056111697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEC54_RS09465 (KEC54_09335) 1975774..1976058 + 285 WP_056111693.1 HigA family addiction module antitoxin Antitoxin
KEC54_RS09470 (KEC54_09340) 1976252..1976455 + 204 WP_003602670.1 50S ribosomal protein L35 -
KEC54_RS09475 (KEC54_09345) 1976508..1976873 + 366 WP_003602669.1 50S ribosomal protein L20 -
KEC54_RS09480 (KEC54_09350) 1977057..1978136 + 1080 WP_015950513.1 phenylalanine--tRNA ligase subunit alpha -
KEC54_RS09485 (KEC54_09355) 1978201..1980624 + 2424 WP_056111691.1 phenylalanine--tRNA ligase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(28-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10784.07 Da        Isoelectric Point: 7.2445

>T199964 WP_056111697.1 NZ_CP073633:1975479-1975760 [Methylorubrum extorquens]
MILSYRNRDTEALDVHGVCHRRWRSFQAAAGRKLDMLNAASVVSDLRSPPGNRLEKLSGDREGQWSIRINDQWRICFRWD
GSGPEDVEIVDYH

Download         Length: 282 bp

>T199964 NZ_CP097670:c4789584-4789051 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10569.16 Da        Isoelectric Point: 9.1081

>AT199964 WP_056111693.1 NZ_CP073633:1975774-1976058 [Methylorubrum extorquens]
MPRIRSHPGEILLEEYLRPLEMSANALAKAIEVPANRISELLRGRRGMTADTACRLGRFFGTTPEFWMSLQTAHDLSRAV
AEHDYSTLRALKSA

Download         Length: 285 bp

>AT199964 NZ_CP097670:c4789861-4789595 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References