Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 778348..778850 Replicon chromosome
Accession NZ_CP073630
Organism Proteus terrae subsp. cibarius strain S24-2-1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KEF19_RS03650 Protein ID WP_075671248.1
Coordinates 778348..778602 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KEF19_RS03655 Protein ID WP_072068851.1
Coordinates 778599..778850 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEF19_RS03625 773682..774179 - 498 WP_075671238.1 Der GTPase-activating protein YihI -
KEF19_RS03630 774368..775840 + 1473 WP_075671240.1 glycosyltransferase family 39 protein -
KEF19_RS03635 775843..776391 + 549 WP_159363623.1 GNAT family N-acetyltransferase -
KEF19_RS03640 776441..776752 - 312 WP_098941657.1 monooxygenase -
KEF19_RS03645 776833..778191 - 1359 WP_075671246.1 NCS2 family permease -
KEF19_RS03650 778348..778602 - 255 WP_075671248.1 Txe/YoeB family addiction module toxin Toxin
KEF19_RS03655 778599..778850 - 252 WP_072068851.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KEF19_RS03660 779081..779833 - 753 WP_075671250.1 amino acid ABC transporter permease -
KEF19_RS03665 779835..780572 - 738 WP_075671252.1 amino acid ABC transporter permease -
KEF19_RS03670 780679..781518 - 840 WP_036933789.1 ABC transporter substrate-binding protein -
KEF19_RS03675 781734..782468 - 735 WP_075671254.1 phosphate signaling complex protein PhoU -
KEF19_RS03680 782483..783259 - 777 WP_006534565.1 phosphate ABC transporter ATP-binding protein PstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10170.78 Da        Isoelectric Point: 9.9411

>T199954 WP_075671248.1 NZ_CP073630:c778602-778348 [Proteus terrae subsp. cibarius]
MKLIFSEQSWSDYLYWQQIDKKIIKRINELIKDIKRTPFSGIGKPEPLKHNLAGFWSRRITDEHRLIYRITDSAIEIASC
RYHY

Download         Length: 255 bp

>T199954 NZ_CP097668:c121787-121476 [Klebsiella pneumoniae]
ATGCACATTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.77 Da        Isoelectric Point: 4.4354

>AT199954 WP_072068851.1 NZ_CP073630:c778850-778599 [Proteus terrae subsp. cibarius]
MKTINYTEARQNLTSIMNETIDDRVPIMITRQKGIPCVLLSLDEYQALEETAYLLRSPANARHLLDSIDELNQGKGIEKD
ITE

Download         Length: 252 bp

>AT199954 NZ_CP097668:c121479-121060 [Klebsiella pneumoniae]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References