Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 800372..801065 Replicon chromosome
Accession NZ_CP073624
Organism Escherichia coli strain AW1.7

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KD735_RS03875 Protein ID WP_000415584.1
Coordinates 800372..800668 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KD735_RS03880 Protein ID WP_000650107.1
Coordinates 800670..801065 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KD735_RS03840 (795506) 795506..795985 + 480 WP_000065333.1 Hcp family type VI secretion system effector -
KD735_RS03845 (795988) 795988..796698 + 711 WP_000834029.1 hypothetical protein -
KD735_RS03850 (796705) 796705..797037 + 333 WP_000914691.1 DUF2645 family protein -
KD735_RS03855 (797083) 797083..798432 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KD735_RS03860 (798429) 798429..799088 - 660 WP_054625965.1 quorum sensing response regulator transcription factor QseB -
KD735_RS03865 (799240) 799240..799632 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KD735_RS03870 (799685) 799685..800167 + 483 WP_054625966.1 GyrI-like domain-containing protein -
KD735_RS03875 (800372) 800372..800668 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KD735_RS03880 (800670) 800670..801065 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KD735_RS03885 (801198) 801198..802805 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KD735_RS03890 (802943) 802943..805201 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T199908 WP_000415584.1 NZ_CP073624:800372-800668 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T199908 NZ_CP097658:329432-329800 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT199908 WP_000650107.1 NZ_CP073624:800670-801065 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT199908 NZ_CP097658:329214-329435 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References