Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 2561389..2562188 | Replicon | chromosome |
| Accession | NZ_CP073589 | ||
| Organism | Escherichia coli strain MFDS1006657 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | U9XVR9 |
| Locus tag | KD154_RS12475 | Protein ID | WP_000347267.1 |
| Coordinates | 2561724..2562188 (+) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | S1EB98 |
| Locus tag | KD154_RS12470 | Protein ID | WP_001307405.1 |
| Coordinates | 2561389..2561724 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KD154_RS12455 (2557174) | 2557174..2557944 | - | 771 | WP_001058227.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
| KD154_RS12460 (2557960) | 2557960..2559294 | - | 1335 | WP_053265295.1 | galactarate/glucarate/glycerate transporter GarP | - |
| KD154_RS12465 (2559669) | 2559669..2561240 | + | 1572 | WP_053265296.1 | galactarate dehydratase | - |
| KD154_RS12470 (2561389) | 2561389..2561724 | + | 336 | WP_001307405.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
| KD154_RS12475 (2561724) | 2561724..2562188 | + | 465 | WP_000347267.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
| KD154_RS12480 (2562243) | 2562243..2563052 | - | 810 | WP_000072187.1 | aga operon transcriptional regulator AgaR | - |
| KD154_RS12485 (2563301) | 2563301..2564581 | + | 1281 | WP_000681933.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
| KD154_RS12490 (2564604) | 2564604..2565077 | + | 474 | WP_053265297.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
| KD154_RS12495 (2565088) | 2565088..2565867 | + | 780 | WP_000406214.1 | PTS N-acetylgalactosamine transporter subunit IIC | - |
| KD154_RS12500 (2565857) | 2565857..2566735 | + | 879 | WP_001298758.1 | PTS N-acetylgalactosamine transporter subunit IID | - |
| KD154_RS12505 (2566753) | 2566753..2567187 | + | 435 | WP_000948824.1 | PTS galactosamine/N-acetylgalactosamine transporter subunit IIA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2550733..2562188 | 11455 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17807.17 Da Isoelectric Point: 9.4947
>T199861 WP_000347267.1 NZ_CP073589:2561724-2562188 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
Download Length: 465 bp
>T199861 NZ_CP097636:1858060-1858359 [Aquincola tertiaricarbonis]
ATGGAGAAACGGACGCCGCACTGCAAGCTGCGGGTGGTCAAGCAGATGGTCACCGAAGGCTTGTGCGAGGCCACCATCAC
TGCGCTTGGCACGGCCAGGGAGATGGGGCTGGGCTTCAGCGATATGAAGCGCGAGTTGCTGCGTCTAGAGGCGCCTAGCT
TTTACAAGAGCATGACCACACATGCGGATCACCGGCTGTGGCAAGACGTCTATCGACACACGCTCGAGAGCGGCCTGAAG
GCCTATGTGAAGCTGACGGTGCATGAGGGTGTGCTGATCGTTTCCTTCAAGGAGTTATGA
ATGGAGAAACGGACGCCGCACTGCAAGCTGCGGGTGGTCAAGCAGATGGTCACCGAAGGCTTGTGCGAGGCCACCATCAC
TGCGCTTGGCACGGCCAGGGAGATGGGGCTGGGCTTCAGCGATATGAAGCGCGAGTTGCTGCGTCTAGAGGCGCCTAGCT
TTTACAAGAGCATGACCACACATGCGGATCACCGGCTGTGGCAAGACGTCTATCGACACACGCTCGAGAGCGGCCTGAAG
GCCTATGTGAAGCTGACGGTGCATGAGGGTGTGCTGATCGTTTCCTTCAAGGAGTTATGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12358.94 Da Isoelectric Point: 4.8616
>AT199861 WP_001307405.1 NZ_CP073589:2561389-2561724 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT199861 NZ_CP097636:1858362-1858763 [Aquincola tertiaricarbonis]
ATGAAATGTCCCCACTGCGGCGGCGCGTCCATGGCAGCCGATACCCGCGATGTCGCTTACACCTACAAGGGGCGGGACAC
CGTCATCCCGCAGGTGACGGGCCGGTTCTGCCCTGCATGCGGTGAGGTGCTGCTCGCGGGCGAACACGCAGAGCGCTACA
GCGATCTGGTAGGGCGGTTTCACAGGGAGGTGAATGCAACTCTGGTGGACCCCGCCTACATCGCTAAGGTGCGTCGCAAG
CTGGCATTAGACCAGCGCGAGGCTGCCGAGATCTTCGGGGGTGGCGTCAACGCGTTCTCCCGTTACGAAACCGGCAAGAC
CAAGCCGCCAGTGGCGTTGATGAAGCTGCTGAAGGTGCTGGACCGGCACCCCGAGCTTCTGCAGGAGGTGAGGGCGGGCT
GA
ATGAAATGTCCCCACTGCGGCGGCGCGTCCATGGCAGCCGATACCCGCGATGTCGCTTACACCTACAAGGGGCGGGACAC
CGTCATCCCGCAGGTGACGGGCCGGTTCTGCCCTGCATGCGGTGAGGTGCTGCTCGCGGGCGAACACGCAGAGCGCTACA
GCGATCTGGTAGGGCGGTTTCACAGGGAGGTGAATGCAACTCTGGTGGACCCCGCCTACATCGCTAAGGTGCGTCGCAAG
CTGGCATTAGACCAGCGCGAGGCTGCCGAGATCTTCGGGGGTGGCGTCAACGCGTTCTCCCGTTACGAAACCGGCAAGAC
CAAGCCGCCAGTGGCGTTGATGAAGCTGCTGAAGGTGCTGGACCGGCACCCCGAGCTTCTGCAGGAGGTGAGGGCGGGCT
GA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XTR4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XVC7 |