Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1312835..1313337 | Replicon | chromosome |
| Accession | NZ_CP073589 | ||
| Organism | Escherichia coli strain MFDS1006657 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | KD154_RS06590 | Protein ID | WP_000767829.1 |
| Coordinates | 1312835..1313089 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | KD154_RS06595 | Protein ID | WP_001259255.1 |
| Coordinates | 1313086..1313337 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KD154_RS06560 (1307850) | 1307850..1308077 | - | 228 | WP_000985280.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| KD154_RS06565 (1308091) | 1308091..1309149 | - | 1059 | WP_000492296.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KD154_RS06570 (1309328) | 1309328..1310686 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| KD154_RS06575 (1310676) | 1310676..1310738 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KD154_RS06580 (1310953) | 1310953..1311882 | - | 930 | WP_047091647.1 | LysR substrate-binding domain-containing protein | - |
| KD154_RS06585 (1311928) | 1311928..1312752 | - | 825 | WP_000754749.1 | SDR family oxidoreductase | - |
| KD154_RS06590 (1312835) | 1312835..1313089 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KD154_RS06595 (1313086) | 1313086..1313337 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KD154_RS06600 (1313620) | 1313620..1313670 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| KD154_RS06605 (1313816) | 1313816..1314715 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| KD154_RS06610 (1314721) | 1314721..1316025 | + | 1305 | WP_001499066.1 | histidinol dehydrogenase | - |
| KD154_RS06615 (1316022) | 1316022..1317092 | + | 1071 | WP_000108950.1 | histidinol-phosphate transaminase | - |
| KD154_RS06620 (1317092) | 1317092..1318159 | + | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T199857 WP_000767829.1 NZ_CP073589:c1313089-1312835 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T199857 NZ_CP097635:1533318-1533617 [Aquincola tertiaricarbonis]
GTGGTCGAGGAGATCCTCGCGCTCCCAGACACGCTCGCTGCCAGGTACGTGGTGCTCACGAGGCGGATCATGGCGGTTGG
GCCGAATCTTGGCGCACCGCACACCGACGCCTTCGGCGAAGGGCTGTTCGAACTGCGGCTCAAAGGCCAGGAAGGCATTG
CCCGAGTCTTCTTCTGTGCGTTAGTCGGGCGCCGGGTGATGATGCTGCACTCCTTCATCAAGAAGACGCAGAGGACACCC
CAACGCGAAATTGAAGTCGCGCGCAAGCGCATGAAAGAGGTCAAGCATGCGAACCCATGA
GTGGTCGAGGAGATCCTCGCGCTCCCAGACACGCTCGCTGCCAGGTACGTGGTGCTCACGAGGCGGATCATGGCGGTTGG
GCCGAATCTTGGCGCACCGCACACCGACGCCTTCGGCGAAGGGCTGTTCGAACTGCGGCTCAAAGGCCAGGAAGGCATTG
CCCGAGTCTTCTTCTGTGCGTTAGTCGGGCGCCGGGTGATGATGCTGCACTCCTTCATCAAGAAGACGCAGAGGACACCC
CAACGCGAAATTGAAGTCGCGCGCAAGCGCATGAAAGAGGTCAAGCATGCGAACCCATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT199857 WP_001259255.1 NZ_CP073589:c1313337-1313086 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT199857 NZ_CP097635:1533604-1533891 [Aquincola tertiaricarbonis]
ATGCGAACCCATGACGATGTCGTTGCCAAGCTCATGAAGCGCCCCGGCGTCCGCAAAGAAGTCGAACGGATCGAACGAGA
GGAAGGCGCACTGCTGGACCTCTTGCTCAAGGCGCGCGAAGAAGCGGGGCTGTCTCAAGCGCAAGTGGCCGAGCGCATGG
GCACCCATGCGCCCGCTGTCGCGCGCCTTGAAAGAGCGCTGGCCACAGGCAAGCACTCGCCTTCGCTCGCCACGCTGAGA
AAGTACGCGCAGGCTTGCGGCAAGACGCTGTCTCTTCACCTCACGTAG
ATGCGAACCCATGACGATGTCGTTGCCAAGCTCATGAAGCGCCCCGGCGTCCGCAAAGAAGTCGAACGGATCGAACGAGA
GGAAGGCGCACTGCTGGACCTCTTGCTCAAGGCGCGCGAAGAAGCGGGGCTGTCTCAAGCGCAAGTGGCCGAGCGCATGG
GCACCCATGCGCCCGCTGTCGCGCGCCTTGAAAGAGCGCTGGCCACAGGCAAGCACTCGCCTTCGCTCGCCACGCTGAGA
AAGTACGCGCAGGCTTGCGGCAAGACGCTGTCTCTTCACCTCACGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|