Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3797091..3797802 Replicon chromosome
Accession NZ_CP073588
Organism Shewanella vesiculosa strain M7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KDH10_RS16625 Protein ID WP_107885219.1
Coordinates 3797512..3797802 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KDH10_RS16620 Protein ID WP_107884986.1
Coordinates 3797091..3797507 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDH10_RS16605 (KDH10_003270) 3792167..3794359 + 2193 WP_124016766.1 glucans biosynthesis glucosyltransferase MdoH -
KDH10_RS16610 (KDH10_003271) 3794623..3796053 + 1431 WP_165870104.1 MFS transporter -
KDH10_RS16615 (KDH10_003272) 3796139..3796795 - 657 WP_235781977.1 sulfotransferase -
KDH10_RS16620 (KDH10_003273) 3797091..3797507 - 417 WP_107884986.1 transcriptional regulator Antitoxin
KDH10_RS16625 (KDH10_003274) 3797512..3797802 - 291 WP_107885219.1 type II toxin-antitoxin system HigB family toxin Toxin
KDH10_RS16630 (KDH10_003275) 3798095..3799726 - 1632 WP_235781696.1 group II intron reverse transcriptase/maturase -
KDH10_RS21090 3800257..3800643 - 387 WP_268921111.1 tyrosine-type recombinase/integrase -
KDH10_RS21095 3800724..3800969 - 246 Protein_3241 tyrosine-type recombinase/integrase -
KDH10_RS16640 3801061..3801216 - 156 WP_235781697.1 phage integrase N-terminal SAM-like domain-containing protein -
KDH10_RS16645 (KDH10_003277) 3801572..3802177 + 606 WP_235781978.1 DUF998 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Antitoxin HigA

(2-138)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11377.82 Da        Isoelectric Point: 9.7376

>T199847 WP_107885219.1 NZ_CP073588:c3797802-3797512 [Shewanella vesiculosa]
VHVISRKPFNDAAQKYPNDRDALVQIYSTLRSGTFTNPDDLRQVFPSLDNFKYRDKWWVIDVGGNNLRIIAFIEFRDNRM
YVKHVVSHADYSRTKE

Download         Length: 291 bp

>T199847 NZ_CP097626:c5064568-5063651 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15460.61 Da        Isoelectric Point: 4.2216

>AT199847 WP_107884986.1 NZ_CP073588:c3797507-3797091 [Shewanella vesiculosa]
MLPTACIEIREALAKVPYLAHIETQDDYEQALALMDDLIDDYDANNFLIEMLSLSIERWEEQTDEFAEFNAAIAELDSGV
AVLKTLMSQYRLGVADLPELGSKSNVSKLLNTVGGKKLNRHHIEALSQRFGVPVSLFF

Download         Length: 417 bp

>AT199847 NZ_CP097626:c5065332-5064574 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References