Detailed information of TA system TA199832

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1092..1518
• Replicon: plasmid p00003
• Accession: NZ_CP073380
• Organism: Klebsiella sp. P1927

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: KB892_RS29935
• Protein ID: WP_001372321.1
• Coordinates: 1092..1217 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	1294..1518 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KB892_RS29930 (477)	477..773	+	297	Protein_1	hypothetical protein	-
KB892_RS29935 (1092)	1092..1217	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
KB892_RS31330 (1159)	1159..1308	-	150	Protein_3	plasmid maintenance protein Mok	-
- (1294)	1294..1518	-	225	NuclAT_0	-	Antitoxin
- (1294)	1294..1518	-	225	NuclAT_0	-	Antitoxin
- (1294)	1294..1518	-	225	NuclAT_0	-	Antitoxin
- (1294)	1294..1518	-	225	NuclAT_0	-	Antitoxin
KB892_RS29940 (1530)	1530..2249	-	720	WP_001276217.1	plasmid SOS inhibition protein A	-
KB892_RS29945 (2246)	2246..2680	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
KB892_RS29950 (2749)	2749..4772	-	2024	Protein_6	ParB/RepB/Spo0J family partition protein	-
KB892_RS29955 (4833)	4833..5066	-	234	WP_000006003.1	DUF905 family protein	-
KB892_RS29960 (5124)	5124..5651	-	528	WP_000290834.1	single-stranded DNA-binding protein	-
KB892_RS31335 (5953)	5953..6402	+	450	Protein_9	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	rmtB / blaTEM-1B / blaCTX-M-65 / catA2 / blaKPC-2	-	1..162093	162093

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T199832 WP_001372321.1 NZ_CP073380:c1217-1092 [Klebsiella sp. P1927]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T199832 NZ_CP097616:1868517-1868843 [Pasteurella multocida]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAGTG
ATTTACGAAGTCCACCTGGTAATAAATTGGAAAAATTGGAGCCTAAAACGAGTGGGCTATATTCTATCAGAGTGAATGTG
AAGTATCGTTTAATATTTAAATATAAAGAAAGTAATTTTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAG
ATTATAA

Antitoxin

Nucleotide

• Length: 225 bp

>AT199832 NZ_CP073380:c1518-1294 [Klebsiella sp. P1927]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin