Detailed information of TA system TA199803

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 889..1158
• Replicon: plasmid p00004
• Accession: NZ_CP073376
• Organism: Klebsiella sp. P1954

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: KB890_RS27130
• Protein ID: WP_001372321.1
• Coordinates: 1033..1158 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	889..954 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KB890_RS27125	1..720	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	732..956	+	225	NuclAT_0	-	-
-	732..956	+	225	NuclAT_0	-	-
-	732..956	+	225	NuclAT_0	-	-
-	732..956	+	225	NuclAT_0	-	-
-	889..954	-	66	-	-	Antitoxin
KB890_RS27650	942..1091	+	150	Protein_2	plasmid maintenance protein Mok	-
KB890_RS27130	1033..1158	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
KB890_RS27135	1477..1773	-	297	Protein_4	hypothetical protein	-
KB890_RS27140	2073..2369	+	297	WP_001272251.1	hypothetical protein	-
KB890_RS27145	2480..3301	+	822	WP_001234445.1	DUF932 domain-containing protein	-
KB890_RS27150	3598..4245	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
KB890_RS27155	4522..4905	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
KB890_RS27160	5096..5782	+	687	WP_015059009.1	PAS domain-containing protein	-
KB890_RS27165	5876..6103	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-55 / blaTEM-1B / rmtB	-	1..55826	55826

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T199803 WP_001372321.1 NZ_CP073376:1033-1158 [Klebsiella sp. P1954]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T199803 NZ_CP097577:c1234464-1234195 [Streptococcus suis]
ATGGCTTATAAACTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGCTGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGCAAGGCCTTGGTTGGAGATTATAAGGGCC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTGATTTGCGATATTATTGATAACAAAATGGTCATCCTAGCTCTTGAAATC
GGACACCGGAAAGAAATCTATAAAAAGTGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT199803 NZ_CP073376:c954-889 [Klebsiella sp. P1954]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin