Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 158651..159378 Replicon plasmid pSDQ8C180-1
Accession NZ_CP073357
Organism Proteus terrae subsp. cibarius strain SDQ8C180-2T

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KDN45_RS18945 Protein ID WP_223674020.1
Coordinates 158651..158962 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KDN45_RS18950 Protein ID WP_045898925.1
Coordinates 158959..159378 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDN45_RS18925 (KDN45_18830) 156153..156317 + 165 Protein_175 DUF4113 domain-containing protein -
KDN45_RS18930 (KDN45_18835) 156464..156745 - 282 WP_000780222.1 helix-turn-helix transcriptional regulator -
KDN45_RS18935 (KDN45_18840) 156726..157055 - 330 WP_024250311.1 type II toxin-antitoxin system RelE/ParE family toxin -
KDN45_RS18940 (KDN45_18845) 157204..158184 + 981 WP_223674021.1 IS5-like element ISKpn26 family transposase -
KDN45_RS18945 (KDN45_18850) 158651..158962 + 312 WP_223674020.1 type II toxin-antitoxin system HigB family toxin Toxin
KDN45_RS18950 (KDN45_18855) 158959..159378 + 420 WP_045898925.1 helix-turn-helix domain-containing protein Antitoxin
KDN45_RS18955 (KDN45_18860) 159382..159585 - 204 WP_045898927.1 hypothetical protein -
KDN45_RS18960 (KDN45_18865) 159662..160359 + 698 WP_223429336.1 IS1 family transposase -
KDN45_RS18965 (KDN45_18870) 160377..160913 + 537 Protein_183 IS30-like element IS30 family transposase -
KDN45_RS18970 (KDN45_18875) 160923..161171 - 249 Protein_184 transposase -
KDN45_RS18975 (KDN45_18880) 161665..162801 + 1137 WP_223674019.1 polysaccharide export protein -
KDN45_RS18980 (KDN45_18885) 162815..163255 + 441 WP_053390280.1 phosphotyrosine protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 157204..169740 12536
- inside Non-Mobilizable plasmid tet(B) / msr(E) / mph(E) / tet(D) / aac(3)-IId / aph(3')-Ia / sul1 / blaDHA-1 / qacE / aadA2 / dfrA12 / floR / sul2 / aph(4)-Ia / aac(3)-IVa / ant(3'')-Ia / dfrA1 / lnu(F) gmd / fcl / manC / ugd 1..192359 192359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12361.09 Da        Isoelectric Point: 9.7248

>T199749 WP_223674020.1 NZ_CP073357:158651-158962 [Proteus terrae subsp. cibarius]
MHLISKEPFEEAAKQYPNDSLAVRALYRLVRETDFSSPAEMRTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE

Download         Length: 312 bp

>T199749 NZ_CP097557:c5065523-5064768 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCGTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15432.60 Da        Isoelectric Point: 4.2699

>AT199749 WP_045898925.1 NZ_CP073357:158959-159378 [Proteus terrae subsp. cibarius]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYLEAIELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEMPV
GVALLRTLIDQYRLSYSDLKEEIGSKSLVSQILSGQRSLTIMHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT199749 NZ_CP097557:c5066026-5065658 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References