Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 739990..740765 Replicon chromosome
Accession NZ_CP073351
Organism Klebsiella pneumoniae strain CP19

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag KBT94_RS03700 Protein ID WP_004150910.1
Coordinates 740280..740765 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag KBT94_RS03695 Protein ID WP_004150912.1
Coordinates 739990..740283 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBT94_RS03675 735198..735800 - 603 WP_062954968.1 short chain dehydrogenase -
KBT94_RS03680 735898..736809 + 912 WP_004188550.1 LysR family transcriptional regulator -
KBT94_RS03685 736810..737958 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
KBT94_RS03690 737969..739345 - 1377 WP_004217775.1 cystathionine beta-synthase -
KBT94_RS03695 739990..740283 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
KBT94_RS03700 740280..740765 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
KBT94_RS03705 741469..742062 + 594 WP_004188553.1 hypothetical protein -
KBT94_RS03710 742159..742375 + 217 Protein_729 transposase -
KBT94_RS03715 742981..743853 + 873 WP_004188557.1 ParA family protein -
KBT94_RS03720 743853..744236 + 384 WP_004150906.1 hypothetical protein -
KBT94_RS03725 744229..745596 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 742159..742311 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T199723 WP_004150910.1 NZ_CP073351:740280-740765 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T199723 NZ_CP097548:67362-67688 [Dinoroseobacter shibae]
TTGAGACGCGGTGAATTGGTGACGGTCGCCCTTCAAGGCGACCACGGAAAGCCGCATCCCGCGCTTGTGATTCAGTCCGA
CCGGTTTCCGGACACGGCCACCACGACCATCCTTATGGTGACGTCCACGCTCGTCAATGCGCCGCTGATCCGGCTGACGG
TTGAGCCCGCGTCGGAAAATGGATTGCGCGCCACGTCGCAAATCATGATCGACAAAGCCATGACTGTCCGAACGGACAAA
CTTCGGGGGGCTTTCGGCCAGCTCGATGATACCGTTATGCTCGAAGTAAATCGGGCGCTGGCGCTGTTTCTGGGTGTGAC
GGGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT199723 WP_004150912.1 NZ_CP073351:739990-740283 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT199723 NZ_CP097548:67147-67365 [Dinoroseobacter shibae]
ATGCCAACCCCTGTTTCTCAACGTGTCAAGAAGCGCCGCGATGTCTTGCGAGCCGCCGGTCTGCGTCCTGTTCAAATCTG
GGTGCCAGATACCCGCCGCCCCGGTTTCGAAACCGAGTGTCGCCGTCAGGCGGCGCTTGTAGCCCAAGCAGATCGCGCCG
ACGTCGGCTTGAACGGCTTCATAGATGCCGCCTTGATTGATATGGACGGATGGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References