Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1477463..1478064 Replicon chromosome
Accession NZ_CP073343
Organism Marinomonas rhizomae strain MB12-11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KDW99_RS06875 Protein ID WP_255828554.1
Coordinates 1477463..1477750 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KDW99_RS06880 Protein ID WP_255828555.1
Coordinates 1477762..1478064 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDW99_RS06850 (KDW99_06835) 1472968..1473696 + 729 WP_255828549.1 hypothetical protein -
KDW99_RS06855 (KDW99_06840) 1473973..1474431 - 459 WP_255828550.1 EVE domain-containing protein -
KDW99_RS06860 (KDW99_06845) 1474586..1475680 + 1095 WP_255828551.1 HD domain-containing phosphohydrolase -
KDW99_RS06865 (KDW99_06850) 1475755..1476681 + 927 WP_255828552.1 histone deacetylase -
KDW99_RS06870 (KDW99_06855) 1476699..1477274 - 576 WP_255828553.1 DUF6151 family protein -
KDW99_RS06875 (KDW99_06860) 1477463..1477750 + 288 WP_255828554.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KDW99_RS06880 (KDW99_06865) 1477762..1478064 + 303 WP_255828555.1 HigA family addiction module antitoxin Antitoxin
KDW99_RS06885 (KDW99_06870) 1478530..1479180 - 651 WP_255828556.1 RluA family pseudouridine synthase -
KDW99_RS06890 (KDW99_06875) 1479187..1482015 - 2829 WP_255828557.1 RNA polymerase-associated protein RapA -
KDW99_RS06895 (KDW99_06880) 1482018..1482635 - 618 WP_255828558.1 YigZ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11514.16 Da        Isoelectric Point: 7.3556

>T199713 WP_255828554.1 NZ_CP073343:1477463-1477750 [Marinomonas rhizomae]
MSLEFKHKWLELFYEEDQRHRLIPKNIENALYRKLEILDAALTESDLRVPPGNRFEHLDGNLQGWCSIRINKQYRLIFQW
NQGIALNTYLDPHKY

Download         Length: 288 bp

>T199713 NZ_CP097529:c1373783-1373469 [Pseudomonas putida]
ATGATCTTCATCGAGACCCCAGTATTCACCTCCGATCTCAAGGAGCACCTGGATGATGAAGAATACCGGGCTTTGCAGGC
CTATCTGGCCGAGCATCCCGAAGCCGGTTCTCTCCTGGAGGAAACCGGCGGCCTCAGAAAGATCCGCTGGGCAGCCAAGG
GCAAGGGCAAGAGTGGGGGTGTACGAGTGATCTACTACCACGTCACTGCAGCCCACCAGATCCGTATGATTCTGATCTAT
CGCAAGGGCATCGTGGATACCTTGACAAGCAGTCAGAAAGCGCAGCTTCGCGCACTAAACAAAGGGTGGAAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11218.12 Da        Isoelectric Point: 10.6985

>AT199713 WP_255828555.1 NZ_CP073343:1477762-1478064 [Marinomonas rhizomae]
MRKTKRRPVSVGEMLKIEFLEPMNITSKALADAMGVHRNTVSSLINGGVLTAPIAIKLAAAFGNTPEFWLNIQHAVDLWD
TRNRYQEEAKQVKPLVAVFR

Download         Length: 303 bp

>AT199713 NZ_CP097529:c1373469-1373182 [Pseudomonas putida]
ATGGAAAAGCATCTCTTCGATCGTCTTGTGGAAAGCATGACTCAGATGGATGAGATCGATCGCGGTGAGCGTCAGCCCTC
GCGTGAGTTCCACGTAGACGCACTTCAAGTCAAAAAGATTCGTCAAGCCACTGGCCTTTCCCAGGCTGCGTTTGCCAAAC
GTATCGATGTCGCAGTAGGAACTCTACGGAATTGGGAACAGGGCCGTCGCGAACCTGAAGGACCAGCTCGTGCCTTGCTT
CGAGCGATTCATAACGATCCCGAACATGTACTTGCGGCCTTGAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References