Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4962819..4963479 Replicon chromosome
Accession NZ_CP073310
Organism Enterobacter cloacae strain CZ862

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KDU74_RS24310 Protein ID WP_167816757.1
Coordinates 4962819..4963193 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KDU74_RS24315 Protein ID WP_014832568.1
Coordinates 4963177..4963479 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDU74_RS24290 (KDU74_24290) 4959060..4959956 + 897 WP_167816756.1 L,D-transpeptidase -
KDU74_RS24300 (KDU74_24300) 4960490..4961413 + 924 WP_178328686.1 nitrogen assimilation transcriptional regulator NAC -
KDU74_RS24305 (KDU74_24305) 4961510..4962460 + 951 WP_047024643.1 HTH-type transcriptional regulator Cbl -
KDU74_RS24310 (KDU74_24310) 4962819..4963193 + 375 WP_167816757.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KDU74_RS24315 (KDU74_24315) 4963177..4963479 + 303 WP_014832568.1 XRE family transcriptional regulator Antitoxin
KDU74_RS24320 (KDU74_24320) 4963575..4964507 - 933 WP_058681724.1 LysR family transcriptional regulator -
KDU74_RS24325 (KDU74_24325) 4964649..4965038 + 390 WP_013097827.1 RidA family protein -
KDU74_RS24330 (KDU74_24330) 4965151..4966137 - 987 WP_058683253.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4965151..4966137 986


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14360.35 Da        Isoelectric Point: 9.7082

>T199708 WP_167816757.1 NZ_CP073310:4962819-4963193 [Enterobacter cloacae]
VWTINTTDRFDCWFRSLDDTDRASVLAALLVLREKGPALSRPYADTLKGSRHSNMKELRIQSKSDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREFTHWLNTLKERTLRDGQKP

Download         Length: 375 bp

>T199708 NZ_CP097528:2846963-2847256 [Pseudomonas putida]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10972.69 Da        Isoelectric Point: 5.1473

>AT199708 WP_014832568.1 NZ_CP073310:4963177-4963479 [Enterobacter cloacae]
MGRNLEQLIADEKSDVVASAQAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLTLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT199708 NZ_CP097528:2846703-2846975 [Pseudomonas putida]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References