Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 124523..124776 | Replicon | plasmid pSW1780-KPC |
| Accession | NZ_CP073303 | ||
| Organism | Klebsiella pneumoniae strain SW1780 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | KCX81_RS27900 | Protein ID | WP_001312851.1 |
| Coordinates | 124627..124776 (+) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 124523..124582 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KCX81_RS27860 (120183) | 120183..120248 | - | 66 | Protein_162 | helix-turn-helix domain-containing protein | - |
| KCX81_RS27865 (120301) | 120301..121005 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| KCX81_RS27870 (121030) | 121030..121230 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| KCX81_RS27875 (121250) | 121250..121996 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| KCX81_RS27880 (122051) | 122051..122611 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| KCX81_RS27885 (122743) | 122743..122943 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| KCX81_RS27890 (123329) | 123329..123928 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| KCX81_RS27895 (123990) | 123990..124322 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (124523) | 124523..124582 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (124523) | 124523..124582 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (124523) | 124523..124582 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (124523) | 124523..124582 | - | 60 | NuclAT_1 | - | Antitoxin |
| KCX81_RS27900 (124627) | 124627..124776 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| KCX81_RS27905 (125060) | 125060..125308 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| KCX81_RS28220 (125423) | 125423..125607 | + | 185 | Protein_172 | protein CopA/IncA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCTX-M-65 / fosA3 / rmtB / blaTEM-1B / blaKPC-2 / catA2 | - | 1..125619 | 125619 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T199688 WP_001312851.1 NZ_CP073303:124627-124776 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T199688 NZ_CP097514:2106297-2106485 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA
Antitoxin
Download Length: 60 bp
>AT199688 NZ_CP073303:c124582-124523 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
