Detailed information of TA system TA199612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 1818954..1819769
• Replicon: chromosome
• Accession: NZ_CP073244
• Organism: Proteus terrae subsp. cibarius strain M878-2

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: KCV11_RS08155
• Protein ID: WP_075673429.1
• Coordinates: 1818954..1819427 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: KCV11_RS08160
• Protein ID: WP_075673430.1
• Coordinates: 1819434..1819769 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCV11_RS08140	1814776..1816971	-	2196	WP_109850422.1	flotillin family protein	-
KCV11_RS08145	1817058..1817693	-	636	WP_109850423.1	DUF1449 family protein	-
KCV11_RS08150	1817996..1818643	-	648	WP_109850424.1	type II CAAX endopeptidase family protein	-
KCV11_RS08155	1818954..1819427	-	474	WP_075673429.1	type II toxin-antitoxin system YhaV family toxin	Toxin
KCV11_RS08160	1819434..1819769	-	336	WP_075673430.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
KCV11_RS08170	1820416..1820988	-	573	WP_098941859.1	transcriptional regulator	-
KCV11_RS08175	1821173..1822498	-	1326	WP_109394971.1	anaerobic C4-dicarboxylate transporter	-
KCV11_RS08180	1822657..1824081	-	1425	WP_211824463.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-147)

Antitoxin

• PrlF antitoxin (15-109)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 18639.26 Da
• Isoelectric Point: 9.2715

>T199612 WP_075673429.1 NZ_CP073244:c1819427-1818954 [Proteus terrae subsp. cibarius]
MDFPTDLNGWTIYAHPCFKQQYDELLQKVEALKKKYPEDYQKKADTKIFAHVLKSIVNITNDPRAPEFRLGNTLGEENKN
WSRIKLVNGRYRLFFRFSFKEKIIILAWINDNDTLRTYGNKTDAYRVFEKKLKKGHPPKNWNDLFSDCINEADCQDP

Nucleotide

• Length: 474 bp

>T199612 NZ_CP097423:1308534-1308944 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12312.67 Da
• Isoelectric Point: 4.2560

>AT199612 WP_075673430.1 NZ_CP073244:c1819769-1819434 [Proteus terrae subsp. cibarius]
MLTHVCTDNIALEADSKITERHQTTIPASIREALHLSGGDRIHYKLLSTGDVLISRHSDGSEDPVMASFLNFLAQDITNH
PQTIQPLDISRGFELVEGMDINLDDDITDNE

Nucleotide

• Length: 336 bp

>AT199612 NZ_CP097423:1308287-1308553 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA