Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1638327..1639087 Replicon chromosome
Accession NZ_CP073238
Organism Pasteurella multocida strain HuN001

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KCI89_RS07590 Protein ID WP_061406326.1
Coordinates 1638327..1638653 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KCI89_RS07595 Protein ID WP_005757699.1
Coordinates 1638761..1639087 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCI89_RS07565 (KCI89_07565) 1633644..1634330 + 687 WP_061406323.1 hypothetical protein -
KCI89_RS07570 (KCI89_07570) 1634384..1635913 - 1530 WP_061406324.1 YifB family Mg chelatase-like AAA ATPase -
KCI89_RS07575 (KCI89_07575) 1636022..1636639 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
KCI89_RS07580 (KCI89_07580) 1636750..1637619 + 870 WP_061406325.1 VirK/YbjX family protein -
KCI89_RS07585 (KCI89_07585) 1637693..1638169 - 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KCI89_RS07590 (KCI89_07590) 1638327..1638653 + 327 WP_061406326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KCI89_RS07595 (KCI89_07595) 1638761..1639087 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
KCI89_RS07600 (KCI89_07600) 1639142..1640662 - 1521 WP_061406327.1 surface lipoprotein assembly modifier -
KCI89_RS07605 (KCI89_07605) 1640721..1641311 - 591 WP_061406438.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
KCI89_RS07610 (KCI89_07610) 1641374..1642384 - 1011 WP_061406328.1 hypothetical protein -
KCI89_RS07615 (KCI89_07615) 1642620..1643651 - 1032 WP_061406329.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12923.75 Da        Isoelectric Point: 9.6705

>T199607 WP_061406326.1 NZ_CP073238:1638327-1638653 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

>T199607 NZ_CP097423:c33696-32779 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT199607 WP_005757699.1 NZ_CP073238:1638761-1639087 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp

>AT199607 NZ_CP097423:c34460-33702 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References