Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5342598..5343193 Replicon chromosome
Accession NZ_CP073082
Organism Pseudomonas aeruginosa strain WTJH17

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KCG37_RS24690 Protein ID WP_071538299.1
Coordinates 5342915..5343193 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KCG37_RS24685 Protein ID WP_003123432.1
Coordinates 5342598..5342903 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG37_RS24650 (KCG37_24650) 5337738..5338586 + 849 WP_003123430.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
KCG37_RS24660 (KCG37_24660) 5338753..5339694 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
KCG37_RS24665 (KCG37_24665) 5339811..5340425 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
KCG37_RS24670 (KCG37_24670) 5340467..5341051 + 585 WP_003123431.1 aminoacyl-tRNA hydrolase -
KCG37_RS24675 (KCG37_24675) 5341092..5342192 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
KCG37_RS24685 (KCG37_24685) 5342598..5342903 - 306 WP_003123432.1 HigA family addiction module antitoxin Antitoxin
KCG37_RS24690 (KCG37_24690) 5342915..5343193 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KCG37_RS32045 5343246..5343374 - 129 Protein_4889 integrase -
KCG37_RS24695 (KCG37_24695) 5343522..5345750 + 2229 WP_003113525.1 TonB-dependent receptor -
KCG37_RS24700 (KCG37_24700) 5345820..5346467 - 648 WP_003095021.1 carbonate dehydratase -
KCG37_RS24705 (KCG37_24705) 5346529..5347767 - 1239 WP_211862484.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T199570 WP_071538299.1 NZ_CP073082:c5343193-5342915 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T199570 NZ_CP097411:794520-794930 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT199570 WP_003123432.1 NZ_CP073082:c5342903-5342598 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT199570 NZ_CP097411:794273-794539 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References