Detailed information of TA system TA199553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 4121983..4122498
• Replicon: chromosome
• Accession: NZ_CP073075
• Organism: Gordonia polyisoprenivorans strain C

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: J8M97_RS18395
• Protein ID: WP_211542394.1
• Coordinates: 4121983..4122237 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: H6N1E7
• Locus tag: J8M97_RS18400
• Protein ID: WP_014359059.1
• Coordinates: 4122238..4122498 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8M97_RS18380 (J8M97_18380)	4117851..4118921	+	1071	WP_211542390.1	phospholipase D-like domain-containing protein	-
J8M97_RS18385 (J8M97_18385)	4118949..4120271	-	1323	WP_249154759.1	alpha/beta hydrolase-fold protein	-
J8M97_RS18390 (J8M97_18390)	4120380..4121861	-	1482	WP_211542392.1	arylsulfotransferase family protein	-
J8M97_RS18395 (J8M97_18395)	4121983..4122237	-	255	WP_211542394.1	Txe/YoeB family addiction module toxin	Toxin
J8M97_RS18400 (J8M97_18400)	4122238..4122498	-	261	WP_014359059.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
J8M97_RS18405 (J8M97_18405)	4122783..4123121	+	339	WP_211542396.1	hypothetical protein	-
J8M97_RS18410 (J8M97_18410)	4123118..4124851	+	1734	WP_249154760.1	hypothetical protein	-
J8M97_RS18415 (J8M97_18415)	4124948..4126186	+	1239	WP_211542398.1	ISL3 family transposase	-
J8M97_RS18420 (J8M97_18420)	4126265..4126783	+	519	WP_249154761.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-69)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9867.28 Da
• Isoelectric Point: 8.0423

>T199553 WP_211542394.1 NZ_CP073075:c4122237-4121983 [Gordonia polyisoprenivorans]
VRLVWDQSAWEDYVHWQTADRRLLKRINTLLGACLRDAFTGIGKPEPLKYGVPGAWSRRISDEHRLVYLVDGDDLIILQA
RYHY

Nucleotide

• Length: 255 bp

>T199553 NZ_CP097385:c1318303-1317770 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9675.74 Da
• Isoelectric Point: 4.4678

>AT199553 WP_014359059.1 NZ_CP073075:c4122498-4122238 [Gordonia polyisoprenivorans]
MSISASEARKLLFPLIEQVNDDRSAIEIVSRKGNAVLMSADEYAAWQETAYLFRSPANARRLLESYTRVSVGQTEVHDLD
RTDEDG

Nucleotide

• Length: 261 bp

>AT199553 NZ_CP097385:c1318580-1318314 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: H6N1E7