Detailed information of TA system TA199551

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1385606..1386251
• Replicon: chromosome
• Accession: NZ_CP073069
• Organism: Vibrio parahaemolyticus strain FB-11

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7Y3Q5T1
• Locus tag: KBU60_RS21690
• Protein ID: WP_025590155.1
• Coordinates: 1385606..1385956 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KBU60_RS21695
• Protein ID: WP_025590153.1
• Coordinates: 1385946..1386251 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KBU60_RS21665 (KBU60_21665)	1380721..1381653	+	933	WP_005462956.1	phosphate ABC transporter permease subunit PstC	-
KBU60_RS21670 (KBU60_21670)	1381676..1382539	+	864	WP_005478161.1	phosphate ABC transporter permease PstA	-
KBU60_RS21675 (KBU60_21675)	1382600..1383349	+	750	WP_020838153.1	phosphate ABC transporter ATP-binding protein PstB	-
KBU60_RS21680 (KBU60_21680)	1383729..1384616	+	888	Protein_1212	GGDEF domain-containing protein	-
KBU60_RS21685 (KBU60_21685)	1384706..1385332	-	627	WP_025590157.1	recombinase family protein	-
KBU60_RS21690 (KBU60_21690)	1385606..1385956	+	351	WP_025590155.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KBU60_RS21695 (KBU60_21695)	1385946..1386251	+	306	WP_025590153.1	XRE family transcriptional regulator	Antitoxin
KBU60_RS21700 (KBU60_21700)	1386742..1388118	+	1377	WP_116920618.1	GGDEF domain-containing protein	-
KBU60_RS21705 (KBU60_21705)	1388460..1390217	-	1758	WP_140326808.1	GGDEF domain-containing response regulator	-
KBU60_RS21710 (KBU60_21710)	1390234..1390662	-	429	WP_025590354.1	response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• HigA2-like, helix-turn-helix domain (14-90)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13441.29 Da
• Isoelectric Point: 4.9860

>T199551 WP_025590155.1 NZ_CP073069:1385606-1385956 [Vibrio parahaemolyticus]
MWNVVTRPLFDEWFLSLDESDQINVRACIQVLLERGPQLSRPYADTVEDSKHSNMKELRVQSNGKPIRAFFAFDPERTGI
ILCGGDKTGDKRFYKKMIPIADAELDEHLEELKNEK

Nucleotide

• Length: 351 bp

>T199551 NZ_CP097383:c5890687-5890409 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCATCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGTGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10928.77 Da
• Isoelectric Point: 8.5752

>AT199551 WP_025590153.1 NZ_CP073069:1385946-1386251 [Vibrio parahaemolyticus]
MKSNPLSVLDAKMSPEALAAAKEKAADMLLDIRLAELREITHLSQVEVAKAMGISQPSVANLEKSGKDLRLSSLKKYIEA
TGGKLRIDVELPDGKHFGFPV

Nucleotide

• Length: 306 bp

>AT199551 NZ_CP097383:c5890397-5890092 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTACGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCCCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: A0A7Y3Q5T1