Detailed information of TA system TA199549

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2474090..2474274
• Replicon: chromosome
• Accession: NZ_CP073065
• Organism: Staphylococcus aureus strain 17Gst354

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KCG41_RS12335
• Protein ID: WP_000482647.1
• Coordinates: 2474167..2474274 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2474090..2474150 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCG41_RS12320	2469544..2469711	-	168	WP_001798790.1	hypothetical protein	-
KCG41_RS12325	2469942..2471675	-	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
KCG41_RS12330	2471700..2473463	-	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
-	2474090..2474150	+	61	-	-	Antitoxin
KCG41_RS12335	2474167..2474274	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
KCG41_RS12340	2474408..2474794	-	387	WP_000779355.1	flippase GtxA	-
KCG41_RS12345	2475061..2476203	+	1143	WP_001176859.1	glycerate kinase	-
KCG41_RS12350	2476263..2476922	+	660	WP_000831300.1	hypothetical protein	-
KCG41_RS12355	2477110..2478321	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
KCG41_RS12360	2478444..2478917	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T199549 WP_000482647.1 NZ_CP073065:c2474274-2474167 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T199549 NZ_CP097383:c5667537-5667247 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT199549 NZ_CP073065:2474090-2474150 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin