Detailed information of TA system TA199542

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2006823..2007130
• Replicon: chromosome
• Accession: NZ_CP073065
• Organism: Staphylococcus aureus strain 17Gst354

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KCG41_RS09835
• Protein ID: WP_011447039.1
• Coordinates: 2006954..2007130 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2006823..2006962 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCG41_RS09795 (2002163)	2002163..2002423	+	261	WP_001791826.1	hypothetical protein	-
KCG41_RS09800 (2002476)	2002476..2002826	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KCG41_RS09805 (2003510)	2003510..2003959	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KCG41_RS09810 (2004054)	2004054..2004389	-	336	Protein_1904	SH3 domain-containing protein	-
KCG41_RS09815 (2005039)	2005039..2005530	-	492	WP_000919350.1	staphylokinase	-
KCG41_RS09820 (2005721)	2005721..2006476	-	756	WP_000861038.1	CHAP domain-containing protein	-
KCG41_RS09825 (2006488)	2006488..2006742	-	255	WP_000611512.1	phage holin	-
KCG41_RS09830 (2006794)	2006794..2006901	+	108	WP_001791821.1	hypothetical protein	-
- (2006823)	2006823..2006962	+	140	NuclAT_0	-	Antitoxin
- (2006823)	2006823..2006962	+	140	NuclAT_0	-	Antitoxin
- (2006823)	2006823..2006962	+	140	NuclAT_0	-	Antitoxin
- (2006823)	2006823..2006962	+	140	NuclAT_0	-	Antitoxin
KCG41_RS09835 (2006954)	2006954..2007130	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KCG41_RS09840 (2007280)	2007280..2007576	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KCG41_RS09845 (2007634)	2007634..2007921	-	288	WP_001040261.1	hypothetical protein	-
KCG41_RS09850 (2007968)	2007968..2008120	-	153	WP_001153681.1	hypothetical protein	-
KCG41_RS09855 (2008110)	2008110..2011895	-	3786	WP_001644870.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2002476..2056634	54158

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T199542 WP_011447039.1 NZ_CP073065:c2007130-2006954 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T199542 NZ_CP097382:11793-12071 [Providencia stuartii]
ATGGAGTTAAAGTGGACGAGCAAAGCATTATCGGATCTCTCTCGAGTCTATGATTTTTTGGCCTTCTCAAACACAGCCGC
TGCAGCGCGTGTTGTGCAAACATTGACGCAAGCACCGGTGTCATTGTTGGTAAATAATCCCCGTATGGGTGAACAATTGT
TCCAATTTATGCCACATGAAGTTCGTCGAGTTGTGGTGGCGAATTATGAGGTACGCTATGAAATCATTGACTCGACAATC
TATATTTTGCGGATATGGCACACTCGGGAAGATCGCTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT199542 NZ_CP073065:2006823-2006962 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin