Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 343571..344150 | Replicon | chromosome |
| Accession | NZ_CP073065 | ||
| Organism | Staphylococcus aureus strain 17Gst354 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | KCG41_RS01550 | Protein ID | WP_001025401.1 |
| Coordinates | 343571..343816 (+) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 343785..344150 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KCG41_RS01490 (338752) | 338752..339366 | + | 615 | WP_000191459.1 | hypothetical protein | - |
| KCG41_RS01495 (339363) | 339363..339509 | - | 147 | WP_001795334.1 | hypothetical protein | - |
| KCG41_RS01500 (339598) | 339598..339993 | - | 396 | WP_001558060.1 | hypothetical protein | - |
| KCG41_RS01505 (340021) | 340021..340455 | - | 435 | WP_119484249.1 | hypothetical protein | - |
| KCG41_RS01510 (340473) | 340473..340934 | - | 462 | WP_212593067.1 | toxin | - |
| KCG41_RS01515 (340947) | 340947..341261 | - | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | - |
| KCG41_RS01520 (341413) | 341413..341649 | + | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| KCG41_RS01525 (341663) | 341663..342439 | + | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| KCG41_RS01530 (342468) | 342468..342617 | + | 150 | WP_000771849.1 | hypothetical protein | - |
| KCG41_RS01535 (342658) | 342658..342870 | - | 213 | WP_000362644.1 | hypothetical protein | - |
| KCG41_RS01540 (342940) | 342940..343137 | + | 198 | WP_001148860.1 | hypothetical protein | - |
| KCG41_RS01545 (343124) | 343124..343504 | - | 381 | WP_000773059.1 | DUF2513 domain-containing protein | - |
| KCG41_RS01550 (343571) | 343571..343816 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| KCG41_RS01555 (343785) | 343785..344150 | - | 366 | WP_016170627.1 | hypothetical protein | Antitoxin |
| KCG41_RS01560 (344205) | 344205..344420 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| KCG41_RS01565 (344445) | 344445..344708 | + | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| KCG41_RS01570 (344721) | 344721..344882 | + | 162 | WP_000048124.1 | DUF1270 family protein | - |
| KCG41_RS01575 (344985) | 344985..345287 | + | 303 | WP_000163429.1 | DUF2482 family protein | - |
| KCG41_RS01580 (345292) | 345292..345552 | + | 261 | WP_031886231.1 | DUF1108 family protein | - |
| KCG41_RS01585 (345562) | 345562..345783 | + | 222 | WP_000815402.1 | DUF2483 family protein | - |
| KCG41_RS01590 (345776) | 345776..346399 | + | 624 | WP_000139720.1 | DUF1071 domain-containing protein | - |
| KCG41_RS01595 (346399) | 346399..346824 | + | 426 | WP_000934384.1 | single-stranded DNA-binding protein | - |
| KCG41_RS01600 (346835) | 346835..347386 | + | 552 | WP_001004506.1 | NUMOD4 domain-containing protein | - |
| KCG41_RS01605 (347387) | 347387..348061 | + | 675 | WP_031775800.1 | putative HNHc nuclease | - |
| KCG41_RS01610 (348054) | 348054..348809 | + | 756 | WP_001037657.1 | DnaD domain protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 337437..383359 | 45922 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T199537 WP_001025401.1 NZ_CP073065:343571-343816 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T199537 NZ_CP097377:1895418-1895885 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA
Antitoxin
Download Length: 366 bp
>AT199537 NZ_CP073065:c344150-343785 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
