Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 67182..67623 Replicon plasmid pDETAB13
Accession NZ_CP073061
Organism Acinetobacter baumannii strain DETAB-P39

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J7D36_RS18630 Protein ID WP_236769085.1
Coordinates 67182..67349 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J7D36_RS18635 Protein ID WP_001258992.1
Coordinates 67336..67623 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7D36_RS18595 (J7D36_18595) 63566..63922 + 357 WP_000269903.1 type II toxin-antitoxin system RelE/ParE family toxin -
J7D36_RS18600 (J7D36_18600) 63915..64217 + 303 WP_001140619.1 XRE family transcriptional regulator -
J7D36_RS18605 (J7D36_18605) 64210..64419 + 210 WP_000069471.1 hypothetical protein -
J7D36_RS18610 (J7D36_18610) 64544..64756 - 213 WP_016653394.1 hypothetical protein -
J7D36_RS18615 (J7D36_18615) 65515..66060 - 546 Protein_68 IS5-like element ISAba13 family transposase -
J7D36_RS18620 (J7D36_18620) 65988..66194 - 207 WP_236769086.1 AAA family ATPase -
J7D36_RS18915 66248..66376 - 129 WP_002123981.1 AAA family ATPase -
J7D36_RS18625 (J7D36_18625) 66564..66884 + 321 WP_016653393.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J7D36_RS18630 (J7D36_18630) 67182..67349 + 168 WP_236769085.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J7D36_RS18635 (J7D36_18635) 67336..67623 + 288 WP_001258992.1 helix-turn-helix transcriptional regulator Antitoxin
J7D36_RS18640 (J7D36_18640) 67907..68131 - 225 WP_016653391.1 hypothetical protein -
J7D36_RS18645 (J7D36_18645) 68155..68712 - 558 Protein_75 hypothetical protein -
J7D36_RS18650 (J7D36_18650) 68752..69771 - 1020 Protein_76 terminase -
J7D36_RS18655 (J7D36_18655) 69844..71052 + 1209 WP_021511398.1 IS256 family transposase -
J7D36_RS18660 (J7D36_18660) 71092..71391 - 300 Protein_78 terminase -
J7D36_RS18665 (J7D36_18665) 71375..71916 - 542 Protein_79 DUF2280 domain-containing protein -
J7D36_RS18670 (J7D36_18670) 71976..72617 - 642 WP_021511117.1 putative metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..91083 91083
- inside IScluster/Tn - - 65515..71052 5537


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-48)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-90)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6408.73 Da        Isoelectric Point: 10.8192

>T199535 WP_236769085.1 NZ_CP073061:67182-67349 [Acinetobacter baumannii]
MRLKSQECIARVMYCTLVGKRIVMLHSFVKKTQKTPKQDLNLALDRMKEVKNANT

Download         Length: 168 bp

>T199535 NZ_CP097377:c1523341-1522970 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10563.32 Da        Isoelectric Point: 9.7308

>AT199535 WP_001258992.1 NZ_CP073061:67336-67623 [Acinetobacter baumannii]
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTALREAGLSQAQIAERMGTNVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV

Download         Length: 288 bp

>AT199535 NZ_CP097377:c1522989-1522696 [Actinobacillus pleuropneumoniae]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATCTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References