Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 63566..64217 | Replicon | plasmid pDETAB13 |
| Accession | NZ_CP073061 | ||
| Organism | Acinetobacter baumannii strain DETAB-P39 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | S3SZA7 |
| Locus tag | J7D36_RS18595 | Protein ID | WP_000269903.1 |
| Coordinates | 63566..63922 (+) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | J7D36_RS18600 | Protein ID | WP_001140619.1 |
| Coordinates | 63915..64217 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7D36_RS18570 (J7D36_18570) | 59398..59820 | + | 423 | WP_006582116.1 | hypothetical protein | - |
| J7D36_RS18575 (J7D36_18575) | 60234..60524 | - | 291 | WP_006582118.1 | putative addiction module antidote protein | - |
| J7D36_RS18580 (J7D36_18580) | 60526..60822 | - | 297 | WP_004647749.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J7D36_RS18585 (J7D36_18585) | 60987..61997 | - | 1011 | WP_006582119.1 | NAD(P)-dependent alcohol dehydrogenase | - |
| J7D36_RS18590 (J7D36_18590) | 62110..63021 | + | 912 | WP_006582120.1 | LysR family transcriptional regulator | - |
| J7D36_RS18595 (J7D36_18595) | 63566..63922 | + | 357 | WP_000269903.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J7D36_RS18600 (J7D36_18600) | 63915..64217 | + | 303 | WP_001140619.1 | XRE family transcriptional regulator | Antitoxin |
| J7D36_RS18605 (J7D36_18605) | 64210..64419 | + | 210 | WP_000069471.1 | hypothetical protein | - |
| J7D36_RS18610 (J7D36_18610) | 64544..64756 | - | 213 | WP_016653394.1 | hypothetical protein | - |
| J7D36_RS18615 (J7D36_18615) | 65515..66060 | - | 546 | Protein_68 | IS5-like element ISAba13 family transposase | - |
| J7D36_RS18620 (J7D36_18620) | 65988..66194 | - | 207 | WP_236769086.1 | AAA family ATPase | - |
| J7D36_RS18915 | 66248..66376 | - | 129 | WP_002123981.1 | AAA family ATPase | - |
| J7D36_RS18625 (J7D36_18625) | 66564..66884 | + | 321 | WP_016653393.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| J7D36_RS18630 (J7D36_18630) | 67182..67349 | + | 168 | WP_236769085.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J7D36_RS18635 (J7D36_18635) | 67336..67623 | + | 288 | WP_001258992.1 | helix-turn-helix transcriptional regulator | - |
| J7D36_RS18640 (J7D36_18640) | 67907..68131 | - | 225 | WP_016653391.1 | hypothetical protein | - |
| J7D36_RS18645 (J7D36_18645) | 68155..68712 | - | 558 | Protein_75 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..91083 | 91083 | |
| - | inside | IScluster/Tn | - | - | 65515..71052 | 5537 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13486.45 Da Isoelectric Point: 7.1645
>T199534 WP_000269903.1 NZ_CP073061:63566-63922 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
Download Length: 357 bp
>T199534 NZ_CP097377:1436976-1437236 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATTCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA
ATGAAGCTAACTTTCTCGTCTAATTCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11206.01 Da Isoelectric Point: 6.7282
>AT199534 WP_001140619.1 NZ_CP073061:63915-64217 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT199534 NZ_CP097377:1436728-1436979 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATTTAGCAGGTACAATGTCAAAAGTAACAGAAGATTTTGAACCTGT
TTTAATTACAAGAAGCAAGGGTGGAAATTGCGTACTTATGTCGTATGAGCAGTATAGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCCCCGGCTAACGCTCAAAGATTACTAGACAGCATGGCAGAATTGAAGCAAGGGAAAGGCATTGAAAGAGAG
CTAATCGAATGA
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATTTAGCAGGTACAATGTCAAAAGTAACAGAAGATTTTGAACCTGT
TTTAATTACAAGAAGCAAGGGTGGAAATTGCGTACTTATGTCGTATGAGCAGTATAGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCCCCGGCTAACGCTCAAAGATTACTAGACAGCATGGCAGAATTGAAGCAAGGGAAAGGCATTGAAAGAGAG
CTAATCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|