199516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3062612..3063306 Replicon chromosome
Accession NZ_CP073013
Organism Marinomonas profundi strain M1K-6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J8N69_RS14250 Protein ID WP_168823442.1
Coordinates 3062938..3063306 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J8N69_RS14245 Protein ID WP_168823440.1
Coordinates 3062612..3062926 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8N69_RS14225 (J8N69_14190) 3058008..3058676 + 669 WP_168823436.1 sarcosine oxidase subunit gamma family protein -
J8N69_RS14230 (J8N69_14195) 3058779..3059645 + 867 WP_168823438.1 formyltetrahydrofolate deformylase -
J8N69_RS14235 (J8N69_14200) 3059823..3060671 + 849 WP_168823510.1 alpha/beta hydrolase -
J8N69_RS14240 (J8N69_14205) 3060789..3062543 + 1755 WP_268921700.1 D-lactate dehydrogenase -
J8N69_RS14245 (J8N69_14210) 3062612..3062926 - 315 WP_168823440.1 XRE family transcriptional regulator Antitoxin
J8N69_RS14250 (J8N69_14215) 3062938..3063306 - 369 WP_168823442.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8N69_RS14255 (J8N69_14220) 3063537..3065033 + 1497 WP_168823444.1 carboxypeptidase M32 -
J8N69_RS17140 (J8N69_14225) 3065689..3066036 + 348 WP_168823445.1 DUF3024 domain-containing protein -
J8N69_RS14265 (J8N69_14230) 3066174..3066788 + 615 WP_168823447.1 FMN-binding negative transcriptional regulator -
J8N69_RS14270 (J8N69_14235) 3066922..3067062 + 141 WP_168823449.1 hypothetical protein -
J8N69_RS14275 (J8N69_14240) 3067169..3067966 - 798 WP_168823514.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-84)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14291.54 Da        Isoelectric Point: 9.4834

>T199516 WP_168823442.1 NZ_CP073013:c3063306-3062938 [Marinomonas profundi]
MIWEILITDEYEQWFLGLTDKEQEDVLSMVDVLEIKGPLLARPYADSLKGTDKVKNLKELRIQHAGKPYRVFYAFDPKRK
VILLCGGRKNGKRNKTFYDKYIPLAEKEFLNYLKNSDSNKTS

Download         Length: 369 bp

>T199516 NZ_CP097370:1944949-1945203 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11383.29 Da        Isoelectric Point: 10.2439

>AT199516 WP_168823440.1 NZ_CP073013:c3062926-3062612 [Marinomonas profundi]
MAKSINELRKKIKPEVQAAARAKAVGIIAEMTLAEVRKKRGINQADLAGFMKIAQPNISQIENRPDALISTLNQYIEALG
GKLEIHAKFPDGQDIEISQFAAVK

Download         Length: 315 bp

>AT199516 NZ_CP097370:1944701-1944952 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References