199511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2055453..2056051 Replicon chromosome
Accession NZ_CP073013
Organism Marinomonas profundi strain M1K-6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J8N69_RS09590 Protein ID WP_168824085.1
Coordinates 2055453..2055776 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J8N69_RS09595 Protein ID WP_168824087.1
Coordinates 2055773..2056051 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8N69_RS09570 (J8N69_09535) 2050709..2052025 + 1317 WP_168824077.1 PAS domain-containing methyl-accepting chemotaxis protein -
J8N69_RS09575 (J8N69_09540) 2052094..2053152 - 1059 WP_168824079.1 iron ABC transporter permease -
J8N69_RS09580 (J8N69_09545) 2053149..2054132 - 984 WP_168824081.1 ABC transporter substrate-binding protein -
J8N69_RS09585 (J8N69_09550) 2054145..2054996 - 852 WP_168824083.1 ABC transporter ATP-binding protein -
J8N69_RS09590 (J8N69_09555) 2055453..2055776 + 324 WP_168824085.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8N69_RS09595 (J8N69_09560) 2055773..2056051 + 279 WP_168824087.1 helix-turn-helix transcriptional regulator Antitoxin
J8N69_RS09600 (J8N69_09565) 2056104..2056715 - 612 WP_168824089.1 glutathione S-transferase family protein -
J8N69_RS09605 (J8N69_09570) 2056975..2057445 + 471 WP_168824091.1 Dps family protein -
J8N69_RS09610 (J8N69_09575) 2057536..2058447 - 912 WP_168824093.1 DMT family transporter -
J8N69_RS09615 (J8N69_09580) 2058658..2059089 + 432 WP_168824095.1 MarR family transcriptional regulator -
J8N69_RS09620 (J8N69_09585) 2059253..2059675 + 423 WP_168824097.1 organic hydroperoxide resistance protein -
J8N69_RS09625 (J8N69_09590) 2059823..2060125 + 303 WP_168824099.1 4a-hydroxytetrahydrobiopterin dehydratase -
J8N69_RS09630 (J8N69_09595) 2060122..2060682 - 561 WP_168824101.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-85)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12416.58 Da        Isoelectric Point: 10.3024

>T199511 WP_168824085.1 NZ_CP073013:2055453-2055776 [Marinomonas profundi]
MTWKIDIYDGVEDQILQMPPKIQSRMIKLLELMEKHGANLGPPHTDSMGNGLFEIRAKAQEGIGRSLFCYLKGKHIYILH
AFVKKSQKTPKNELELARQRQKEVQKR

Download         Length: 324 bp

>T199511 NZ_CP097370:c663616-663152 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10443.96 Da        Isoelectric Point: 9.6014

>AT199511 WP_168824087.1 NZ_CP073013:2055773-2056051 [Marinomonas profundi]
MSLQKLKQRALENSDVKAEYDKLEAEFNFIDQLLSMRTKAGLTQEQVAEKMNTQKSNISRLERGNANPSWATLLKYAHAC
GFELSLKAQKVP

Download         Length: 279 bp

>AT199511 NZ_CP097370:c663951-663616 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References