Detailed information of TA system TA199499

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2508614..2508794
• Replicon: chromosome
• Accession: NZ_CP073012
• Organism: Staphylococcus aureus strain SA14+

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KAJ74_RS12330
• Protein ID: WP_001801861.1
• Coordinates: 2508699..2508794 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2508614..2508671 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAJ74_RS12315 (KAJ74_12315)	2504189..2504950	+	762	WP_224684922.1	DNA adenine methylase	-
KAJ74_RS12320 (KAJ74_12320)	2504921..2506093	-	1173	WP_000195429.1	IS256-like element IS256 family transposase	-
KAJ74_RS14315	2506353..2506862	+	510	WP_224684909.1	hypothetical protein	-
KAJ74_RS12325 (KAJ74_12325)	2506924..2508048	+	1125	WP_223876714.1	hypothetical protein	-
KAJ74_RS14320	2508478..2508576	-	99	Protein_2399	hypothetical protein	-
-	2508614..2508671	+	58	-	-	Antitoxin
KAJ74_RS12330 (KAJ74_12330)	2508699..2508794	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
KAJ74_RS14350	2508939..2509070	+	132	WP_001808010.1	hypothetical protein	-
KAJ74_RS12340 (KAJ74_12340)	2509246..2509692	+	447	WP_000747805.1	DUF1433 domain-containing protein	-
KAJ74_RS12345 (KAJ74_12345)	2509806..2510432	+	627	Protein_2403	ImmA/IrrE family metallo-endopeptidase	-
KAJ74_RS12350 (KAJ74_12350)	2510564..2511316	-	753	WP_000764922.1	staphylococcal enterotoxin type 27	-
KAJ74_RS12355 (KAJ74_12355)	2511343..2512026	-	684	WP_000957233.1	exotoxin beta-grasp domain-containing protein	-
KAJ74_RS12360 (KAJ74_12360)	2512113..2512739	-	627	WP_000669028.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk	2484666..2515297	30631
	-	flank	IS/Tn	-	-	2504921..2506093	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T199499 WP_001801861.1 NZ_CP073012:c2508794-2508699 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T199499 NZ_CP097367:c3713354-3712434 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT199499 NZ_CP073012:2508614-2508671 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin