Detailed information of TA system TA199493

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2215156..2215434
• Replicon: chromosome
• Accession: NZ_CP073012
• Organism: Staphylococcus aureus strain SA14+

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KAJ74_RS10700
• Protein ID: WP_001802298.1
• Coordinates: 2215156..2215260 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2215256..2215434 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAJ74_RS10685 (KAJ74_10685)	2211953..2212735	+	783	WP_031590911.1	ABC transporter ATP-binding protein	-
KAJ74_RS10690 (KAJ74_10690)	2212803..2213660	+	858	WP_000370930.1	HAD family hydrolase	-
KAJ74_RS10695 (KAJ74_10695)	2214318..2214476	-	159	WP_001792784.1	hypothetical protein	-
KAJ74_RS10700 (KAJ74_10700)	2215156..2215260	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2215256..2215434	-	179	-	-	Antitoxin
KAJ74_RS10705 (KAJ74_10705)	2215702..2216793	-	1092	WP_000495681.1	hypothetical protein	-
KAJ74_RS10710 (KAJ74_10710)	2217059..2218039	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
KAJ74_RS10715 (KAJ74_10715)	2218041..2218361	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KAJ74_RS10720 (KAJ74_10720)	2218513..2219178	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T199493 WP_001802298.1 NZ_CP073012:2215156-2215260 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T199493 NZ_CP097367:c1965272-1964898 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT199493 NZ_CP073012:c2215434-2215256 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin