Detailed information of TA system TA199457

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 161758..162027
• Replicon: plasmid p1878-163k
• Accession: NZ_CP072998
• Organism: Klebsiella pneumoniae strain KP1878

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: KA532_RS28960
• Protein ID: WP_001372321.1
• Coordinates: 161902..162027 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	161758..161823 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KA532_RS28935	157468..157995	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
KA532_RS28940	158053..158286	+	234	WP_000006003.1	DUF905 family protein	-
KA532_RS28945	158347..160370	+	2024	Protein_211	ParB/RepB/Spo0J family partition protein	-
KA532_RS28950	160439..160873	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
KA532_RS28955	160870..161589	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	161601..161825	+	225	NuclAT_0	-	-
-	161601..161825	+	225	NuclAT_0	-	-
-	161601..161825	+	225	NuclAT_0	-	-
-	161601..161825	+	225	NuclAT_0	-	-
-	161758..161823	-	66	-	-	Antitoxin
KA532_RS29455	161811..161960	+	150	Protein_214	plasmid maintenance protein Mok	-
KA532_RS28960	161902..162027	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
KA532_RS28965	162346..162642	-	297	Protein_216	hypothetical protein	-
KA532_RS28970	162942..163238	+	297	WP_001272251.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	catA2 / blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB	-	1..163348	163348

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T199457 WP_001372321.1 NZ_CP072998:161902-162027 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T199457 NZ_CP097355:c1895932-1895645 [Vibrio parahaemolyticus]
ATGAAAGTAGTCTGGTCTCCATTAGCTCTTCAGAAACTAGGCGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
GGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCATACGAATTATCGCGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATTCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT199457 NZ_CP072998:c161823-161758 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin