Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 99621..100348 | Replicon | plasmid p1878-217k |
| Accession | NZ_CP072997 | ||
| Organism | Klebsiella pneumoniae strain KP1878 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | KA532_RS27315 | Protein ID | WP_011251285.1 |
| Coordinates | 99621..99932 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KA532_RS27320 | Protein ID | WP_011251286.1 |
| Coordinates | 99929..100348 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KA532_RS27275 (KA532_27275) | 94682..95197 | - | 516 | WP_094819131.1 | hypothetical protein | - |
| KA532_RS27280 (KA532_27280) | 95305..95880 | - | 576 | WP_074424927.1 | hypothetical protein | - |
| KA532_RS27285 (KA532_27285) | 95997..96953 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| KA532_RS27290 (KA532_27290) | 97013..97354 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| KA532_RS27295 (KA532_27295) | 97368..97679 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| KA532_RS27300 (KA532_27300) | 97696..98145 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| KA532_RS27310 (KA532_27310) | 98979..99416 | + | 438 | Protein_117 | DDE-type integrase/transposase/recombinase | - |
| KA532_RS27315 (KA532_27315) | 99621..99932 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| KA532_RS27320 (KA532_27320) | 99929..100348 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| KA532_RS27325 (KA532_27325) | 100495..101463 | + | 969 | WP_086642568.1 | IS5 family transposase | - |
| KA532_RS27330 (KA532_27330) | 101535..101900 | - | 366 | WP_048333448.1 | hypothetical protein | - |
| KA532_RS29395 | 101914..102321 | - | 408 | WP_227630754.1 | hypothetical protein | - |
| KA532_RS27340 (KA532_27340) | 102655..103623 | - | 969 | WP_004225014.1 | IS5 family transposase | - |
| KA532_RS27345 (KA532_27345) | 103656..104894 | - | 1239 | Protein_124 | copper/silver sensor histidine kinase SilS | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | rmpA / iutA / iucD / iucC / iucB / iucA / rmpA | 1..217255 | 217255 | |
| - | inside | IScluster/Tn | - | - | 98147..103623 | 5476 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T199452 WP_011251285.1 NZ_CP072997:99621-99932 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T199452 NZ_CP097346:c111319-110903 [Enterobacter hormaechei subsp. xiangfangensis]
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTCCAGCTGGTCGATGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGAT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCACTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCATGCCATCGCCGCCGGCGCGGTACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTCCAGCTGGTCGATGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGAT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCACTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCATGCCATCGCCGCCGGCGCGGTACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT199452 WP_011251286.1 NZ_CP072997:99929-100348 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT199452 NZ_CP097346:c111546-111316 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGGTCGTTCGCGCAGCTCG
AAAAAGCCGATCCGGACTTTATGGCGGAGCGCGGGGACGTTGTCAGCGACGAAGGAAGATTTAACCTGTGA
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGGTCGTTCGCGCAGCTCG
AAAAAGCCGATCCGGACTTTATGGCGGAGCGCGGGGACGTTGTCAGCGACGAAGGAAGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|