Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 720455..721148 Replicon chromosome
Accession NZ_CP072986
Organism Escherichia coli strain T159A

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KBW97_RS03475 Protein ID WP_000415584.1
Coordinates 720455..720751 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KBW97_RS03480 Protein ID WP_000650107.1
Coordinates 720753..721148 (+) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBW97_RS03440 (715543) 715543..715857 - 315 WP_000958598.1 putative quinol monooxygenase -
KBW97_RS03445 (715888) 715888..716469 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KBW97_RS03450 (716788) 716788..717120 + 333 WP_000917684.1 DUF2645 family protein -
KBW97_RS03455 (717166) 717166..718515 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KBW97_RS03460 (718512) 718512..719171 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
KBW97_RS03465 (719323) 719323..719715 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KBW97_RS03470 (719768) 719768..720250 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KBW97_RS03475 (720455) 720455..720751 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KBW97_RS03480 (720753) 720753..721148 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KBW97_RS03485 (721281) 721281..722888 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KBW97_RS03490 (723026) 723026..725284 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T199398 WP_000415584.1 NZ_CP072986:720455-720751 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T199398 NZ_CP097336:c824495-824220 [Mannheimia haemolytica]
ATGGTAGTAAAAATCCTAAAGCGGAAATCTCAAAAGACATTACAACAAATCTACACCCAGCCTATTTCTGCCAATATTAA
ATGGACAAATATAGAAGCTCTTTTTCTAGAGTTAGGAGCAGAAATAGAAGAACGAGAAGGGAGCAGAATTGCAGTTGTTT
TATTTCAACAGGTCAGAGTATTTCATCGCCCACACCCTAATCCTGATACAGATAAGGGGGCAGTAGCGAGTATTAAAAAA
TGGTTATCTGAAAACGGAGTCATTCCTTATGCGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT199398 WP_000650107.1 NZ_CP072986:720753-721148 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT199398 NZ_CP097336:c824227-823898 [Mannheimia haemolytica]
ATGCGTAATATTATGGATATTAATGGTTATAAAGCTGTTATTGCTTACGATCCCGAAACAGAATTATTTCGAGGTGAATT
TATCGGATTAAATGGTGGAGCCGATTTTTATGCCGATAATGTCATTCAATTAAAAAAAGAAGGGGAACTAAGTTTGAATA
TCTTTTTAGAACTTTGTAGAGAAAAAGGTATTGAGCCGTTCAAACAATATTCCGGAAAGTTTAATGTTCGCCTTTCGCCT
GAATTACATAAAGCTGCGGTAATTGCAGCAACTGCTGAAAATTTAAGCTTAAATGAATGGATTAACCAAACGTTAGAAAA
GAGCGTGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References