Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 45099..45363 | Replicon | plasmid pEC2341_3 |
| Accession | NZ_CP072978 | ||
| Organism | Escherichia coli strain EC2341 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | KBW65_RS23925 | Protein ID | WP_001387489.1 |
| Coordinates | 45099..45251 (-) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 45303..45363 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KBW65_RS23895 (40365) | 40365..42533 | + | 2169 | WP_015508354.1 | DotA/TraY family protein | - |
| KBW65_RS23900 (42604) | 42604..43266 | + | 663 | WP_012783935.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| KBW65_RS23905 (43338) | 43338..43547 | - | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| KBW65_RS23910 (43939) | 43939..44115 | + | 177 | WP_001054900.1 | hypothetical protein | - |
| KBW65_RS25245 (44180) | 44180..44275 | - | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| KBW65_RS23920 (44776) | 44776..45027 | + | 252 | WP_001291964.1 | hypothetical protein | - |
| KBW65_RS23925 (45099) | 45099..45251 | - | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| - (45303) | 45303..45363 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (45303) | 45303..45363 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (45303) | 45303..45363 | + | 61 | NuclAT_0 | - | Antitoxin |
| - (45303) | 45303..45363 | + | 61 | NuclAT_0 | - | Antitoxin |
| KBW65_RS23930 (45878) | 45878..46657 | + | 780 | WP_275450201.1 | protein FinQ | - |
| - (46727) | 46727..46784 | + | 58 | NuclAT_1 | - | - |
| - (46727) | 46727..46784 | + | 58 | NuclAT_1 | - | - |
| - (46727) | 46727..46784 | + | 58 | NuclAT_1 | - | - |
| - (46727) | 46727..46784 | + | 58 | NuclAT_1 | - | - |
| KBW65_RS23935 (46964) | 46964..48172 | + | 1209 | WP_001703845.1 | IncI1-type conjugal transfer protein TrbA | - |
| KBW65_RS23940 (48191) | 48191..49261 | + | 1071 | WP_210833313.1 | DsbC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..107480 | 107480 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T199355 WP_001387489.1 NZ_CP072978:c45251-45099 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T199355 NZ_CP097327:2106335-2106667 [Providencia vermicola]
ATGGTATCTCGATACGTTCCTGATTCTGGCGATTTGATTTGGATTGACTTTGATCCAGTTGAAGGACATGAGCAGGGCGG
TCATCGTCCAGCAGTTGTCCTCAGCCCATTTGCATACAATAATAAAGTAGGGCTCTTATTATGCGTACCATGTACAACTA
AGGGCAAAGGCTATCCATTTGAATGCGAACTCTCGAACGAAAGAGACAGCTACGCATTAGCGGATCAAGTTACATGTGTT
GACTGGAGAGCTCGTAAGGTTACTAAAAAGGGCAAAGTGGAGGCATCAGAACTGGCAGAGATAAAAGCTAAAGCAAAGGC
GTTAATAGGTTAG
ATGGTATCTCGATACGTTCCTGATTCTGGCGATTTGATTTGGATTGACTTTGATCCAGTTGAAGGACATGAGCAGGGCGG
TCATCGTCCAGCAGTTGTCCTCAGCCCATTTGCATACAATAATAAAGTAGGGCTCTTATTATGCGTACCATGTACAACTA
AGGGCAAAGGCTATCCATTTGAATGCGAACTCTCGAACGAAAGAGACAGCTACGCATTAGCGGATCAAGTTACATGTGTT
GACTGGAGAGCTCGTAAGGTTACTAAAAAGGGCAAAGTGGAGGCATCAGAACTGGCAGAGATAAAAGCTAAAGCAAAGGC
GTTAATAGGTTAG
Antitoxin
Download Length: 61 bp
>AT199355 NZ_CP072978:45303-45363 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
