Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 3896708..3897210 | Replicon | chromosome |
| Accession | NZ_CP072976 | ||
| Organism | Escherichia coli strain EC2341 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | KBW65_RS18605 | Protein ID | WP_000767829.1 |
| Coordinates | 3896956..3897210 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | KBW65_RS18600 | Protein ID | WP_001259255.1 |
| Coordinates | 3896708..3896959 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KBW65_RS18575 (3891885) | 3891885..3892952 | - | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| KBW65_RS18580 (3892952) | 3892952..3894022 | - | 1071 | WP_053908449.1 | histidinol-phosphate transaminase | - |
| KBW65_RS18585 (3894019) | 3894019..3895323 | - | 1305 | WP_053908451.1 | histidinol dehydrogenase | - |
| KBW65_RS18590 (3895329) | 3895329..3896228 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| KBW65_RS18595 (3896374) | 3896374..3896424 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| KBW65_RS18600 (3896708) | 3896708..3896959 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KBW65_RS18605 (3896956) | 3896956..3897210 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KBW65_RS18610 (3897293) | 3897293..3898117 | + | 825 | WP_053908453.1 | SDR family oxidoreductase | - |
| KBW65_RS18615 (3898163) | 3898163..3899092 | + | 930 | WP_053908455.1 | LysR substrate-binding domain-containing protein | - |
| KBW65_RS18620 (3899307) | 3899307..3899369 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KBW65_RS18625 (3899359) | 3899359..3900717 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| KBW65_RS18630 (3900896) | 3900896..3901954 | + | 1059 | WP_053908457.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KBW65_RS18635 (3901968) | 3901968..3902195 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T199338 WP_000767829.1 NZ_CP072976:3896956-3897210 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T199338 NZ_CP097322:2337268-2337522 [Streptomyces sp. RerS4]
GTGAAGGTGGTGTTCTCCAGCCGTGCGTGGGACCAGTACACCTACTGGACGACGGCCGATCCGAAGATCCTCAAGAGGAT
CAATCGGCTGATCAAGGAGATTCAGCGAACACCGTTCGAAGGCGCCGGGAAGCCCGAACCGCTCAAGGAGAGCCTCTCCG
GATGGTGGTCCCGGCGCATCACGGACGAGCACCGTCTCGTCTACCGGATCAGGGACGAGGCCGTCGAAATCGCGCAGGCG
CGGTACCACTACTGA
GTGAAGGTGGTGTTCTCCAGCCGTGCGTGGGACCAGTACACCTACTGGACGACGGCCGATCCGAAGATCCTCAAGAGGAT
CAATCGGCTGATCAAGGAGATTCAGCGAACACCGTTCGAAGGCGCCGGGAAGCCCGAACCGCTCAAGGAGAGCCTCTCCG
GATGGTGGTCCCGGCGCATCACGGACGAGCACCGTCTCGTCTACCGGATCAGGGACGAGGCCGTCGAAATCGCGCAGGCG
CGGTACCACTACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT199338 WP_001259255.1 NZ_CP072976:3896708-3896959 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT199338 NZ_CP097322:2336996-2337271 [Streptomyces sp. RerS4]
ATGCCGATCTCGGCGAACGAGGCCCGCACCCGCTTCTACCCGTTGATCCGGCAGGTCAACGAGGATCACGAACCGATAGA
GGTCACCTCCCGCGAGCACGGCGATGTCGTCATCATGTCCGCCGAGGACTTCCGGTCCTGGCAGGAGACGGTCTACCTCC
TGCGTTCGCCCCGCAACGCGCAGATCCTCATGGAGTCCATCGCCGAGCTCGACGCCGGCCACGGGCAGGCGCGTGAACTC
GTCGAAACGACGGATGACGCGGAGTCCGCCGCGTGA
ATGCCGATCTCGGCGAACGAGGCCCGCACCCGCTTCTACCCGTTGATCCGGCAGGTCAACGAGGATCACGAACCGATAGA
GGTCACCTCCCGCGAGCACGGCGATGTCGTCATCATGTCCGCCGAGGACTTCCGGTCCTGGCAGGAGACGGTCTACCTCC
TGCGTTCGCCCCGCAACGCGCAGATCCTCATGGAGTCCATCGCCGAGCTCGACGCCGGCCACGGGCAGGCGCGTGAACTC
GTCGAAACGACGGATGACGCGGAGTCCGCCGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|