Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2828473..2829166 Replicon chromosome
Accession NZ_CP072976
Organism Escherichia coli strain EC2341

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag KBW65_RS13600 Protein ID WP_000415585.1
Coordinates 2828473..2828769 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KBW65_RS13605 Protein ID WP_000650107.1
Coordinates 2828771..2829166 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBW65_RS24990 (2823607) 2823607..2824086 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
KBW65_RS24995 (2824089) 2824089..2824799 + 711 WP_000834030.1 hypothetical protein -
KBW65_RS13575 (2824806) 2824806..2825138 + 333 WP_000914690.1 DUF2645 family protein -
KBW65_RS13580 (2825184) 2825184..2826533 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
KBW65_RS13585 (2826530) 2826530..2827189 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
KBW65_RS13590 (2827341) 2827341..2827733 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KBW65_RS13595 (2827786) 2827786..2828268 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KBW65_RS13600 (2828473) 2828473..2828769 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
KBW65_RS13605 (2828771) 2828771..2829166 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KBW65_RS13610 (2829299) 2829299..2830906 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
KBW65_RS13615 (2831044) 2831044..2833302 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T199333 WP_000415585.1 NZ_CP072976:2828473-2828769 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T199333 NZ_CP097320:c3634556-3634164 [Candidatus Mycobacterium methanotrophicum]
ATGACCACGGTGGTGCTCGACTCGCACGTGATCCACTGGTGGGCGGCGGAGCCTCGGCGCCTGAGTCCCACCGCCAGCCG
GGCCATCGAGCAGGCCGACGAGCTCGCCGTCGCCGCCATCAGCTGGTACGAGTTGGCGTGGCTCGCCGAGCACGAGCGTA
TCCAGACGACGATTCCGCTGCGATCCTGGCTTGCGCAGCTGGCCGAGCACGTCCGCACGATCGGCATCACTCCCGCCGTC
GCCGCCACGGCAGCGTCGTTGCCGTCCGGGTTTCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCCGTCGAACA
CGGCTGGCCTCTGGTGACCAAGGATCAACGGCTGCGCAACCACCGGTATCCGCGTCCGGTCACTGTGTGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT199333 WP_000650107.1 NZ_CP072976:2828771-2829166 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT199333 NZ_CP097320:c3634803-3634588 [Candidatus Mycobacterium methanotrophicum]
ATGACCGCTACTGAGGTGAAGGCGAAGATCCTTGCTCTGCTCGACGACGTCGCCGACGGCGAGGAAATCGAGATCACCAA
ACACGGCCGGACGGTGGCCCGACTGGTGGCAGCGACCGGGCCACACGCACTCAAGGGCCGGTTGGCTGGGGTTGCGATGA
CGGCCGCCGATGACGACGAGCTATTCACCACCGGTCAGTCCTGGAACGCCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References