Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1189082..1189809 Replicon chromosome
Accession NZ_CP072953
Organism Enterobacter sp. MGH 3

Toxin (Protein)


Gene name higB Uniprot ID A0A8B3V067
Locus tag IBG19_RS05505 Protein ID WP_022650547.1
Coordinates 1189498..1189809 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B3V464
Locus tag IBG19_RS05500 Protein ID WP_022650546.1
Coordinates 1189082..1189501 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG19_RS05485 1186154..1187275 - 1122 WP_003858868.1 YbdK family carboxylate-amine ligase -
IBG19_RS05490 1187381..1188271 + 891 WP_022650544.1 oxidoreductase -
IBG19_RS05495 1188324..1188758 - 435 WP_022650545.1 hypothetical protein -
IBG19_RS05500 1189082..1189501 - 420 WP_022650546.1 helix-turn-helix domain-containing protein Antitoxin
IBG19_RS05505 1189498..1189809 - 312 WP_022650547.1 type II toxin-antitoxin system HigB family toxin Toxin
IBG19_RS25390 1190265..1190921 + 657 WP_022650548.1 hypothetical protein -
IBG19_RS05515 1191034..1191489 - 456 WP_022650549.1 hypothetical protein -
IBG19_RS05520 1191772..1192653 - 882 WP_022650550.1 LysR family transcriptional regulator -
IBG19_RS05525 1192759..1193538 + 780 WP_003858848.1 acetolactate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12554.34 Da        Isoelectric Point: 9.9435

>T199279 WP_022650547.1 NZ_CP072953:c1189809-1189498 [Enterobacter sp. MGH 3]
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPSPDEMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKF
FIKHISTHAEYDKLTDYYRRTKE

Download         Length: 312 bp

>T199279 NZ_CP097262:c4072765-4072481 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15447.51 Da        Isoelectric Point: 4.6051

>AT199279 WP_022650546.1 NZ_CP072953:c1189501-1189082 [Enterobacter sp. MGH 3]
MNYAAAIKAANALTNELPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVEMLTAKIDKYENESPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN

Download         Length: 420 bp

>AT199279 NZ_CP097262:c4072997-4072755 [Salmonella enterica subsp. enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3V067

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3V464

References