Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 348929..349575 Replicon chromosome
Accession NZ_CP072949
Organism Klebsiella pneumoniae MGH 39

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag IBD60_RS01605 Protein ID WP_016529833.1
Coordinates 348929..349276 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag IBD60_RS01610 Protein ID WP_004174017.1
Coordinates 349276..349575 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBD60_RS01595 344855..346288 + 1434 WP_002920564.1 glycogen synthase GlgA -
IBD60_RS01600 346306..348753 + 2448 WP_002920561.1 glycogen phosphorylase -
IBD60_RS01605 348929..349276 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IBD60_RS01610 349276..349575 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
IBD60_RS01615 349638..351146 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
IBD60_RS01620 351351..351680 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
IBD60_RS01625 351731..352561 + 831 WP_032428425.1 rhomboid family intramembrane serine protease GlpG -
IBD60_RS01630 352611..353369 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T199255 WP_016529833.1 NZ_CP072949:348929-349276 [Klebsiella pneumoniae MGH 39]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T199255 NZ_CP097255:3573177-3573476 [Enterobacter bugandensis]
ATGATTAATCATTTTCGTGATCAATGGCTTAAGGATTTTTTTCTGTACGGGAAATCAAGCAATGTGATCCCTTCAAGCCT
TGAATCAGCCTTAGCGAGGAAGCTGGATATGATCAACGCTGCCACCTCGCACCGGGAGCTGAGATCCCCGCCAGGCAATA
TGTATGAATCGCTGAATCCCCCGCTTGCAGGGTACTCTGCGATTCGCGTTAACAGGCAATACAGGTTGGTATTCAGGTGG
TCAGAGGGCAAAGCAGACGATCTCTACCTCTCTCCGCACAAGTACACGCCATACAAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT199255 WP_004174017.1 NZ_CP072949:349276-349575 [Klebsiella pneumoniae MGH 39]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT199255 NZ_CP097255:3573487-3573834 [Enterobacter bugandensis]
ATGACTCTTCAACAGGCTCTACGCAAACCCACCACGCCGGGCGATGTGTTGCAGTATGAATATCTTGAGCCGCTCAATCT
GAAAATTAGCGATCTCGCGGAAATGCTTAACGTGCACCGTAATACCATCAGTGCTCTCGTTAATAATAATCGTAAACTGA
CGGCCGATATGGCAATCAGACTGGCCAAGGCATTCGATACCACCATTGAATTCTGGTTGAACCTGCAGCTAAACGTCGAC
GTCTGGGAAGCACAAACCAATTCACGGACTCAGGAGGAGTTGAGCCGTATAAAAACGATTGCAGAAATCATGGCAAAAAG
GAAATCAGGCCAGCCGGATGTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References