Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3722413..3723070 Replicon chromosome
Accession NZ_CP072945
Organism Enterobacter sp. MGH 7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IAU58_RS17910 Protein ID WP_032609983.1
Coordinates 3722413..3722712 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAU58_RS17915 Protein ID WP_032609984.1
Coordinates 3722723..3723070 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAU58_RS17900 3718790..3720982 + 2193 WP_032609980.1 type I secretion system permease/ATPase -
IAU58_RS17905 3720963..3722162 + 1200 WP_032609982.1 HlyD family efflux transporter periplasmic adaptor subunit -
IAU58_RS17910 3722413..3722712 + 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IAU58_RS17915 3722723..3723070 + 348 WP_032609984.1 HigA family addiction module antitoxin Antitoxin
IAU58_RS17920 3723146..3724327 - 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
IAU58_RS17925 3724348..3725235 - 888 WP_022651703.1 LysR family transcriptional regulator -
IAU58_RS17930 3725333..3725935 + 603 WP_022651704.1 short chain dehydrogenase -
IAU58_RS17935 3725932..3726663 - 732 WP_022651705.1 class I SAM-dependent methyltransferase -
IAU58_RS17940 3726738..3727736 - 999 WP_022651706.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T199250 WP_032609983.1 NZ_CP072945:3722413-3722712 [Enterobacter sp. MGH 7]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T199250 NZ_CP097254:c12290-11796 [Enterobacter bugandensis]
ATGGAATACTTAGAATTAAATGGTTGGAAAATCTGCTTTCACAAATGCTTTTTAGACCAGATTGCGGAGCTTGCGCAGAA
GGTCGCTGAGTTAAAAGCAGCAAAACCCAACGAATACCATAAGAAAAAAGAAACTAAGCTCCTGCTTGCGATTGAGCGAG
TGATTGAGGAATGGATTGCTTCAGATCCGCTCAATCCTCAGTACCGCCAGGGCGACACTTTAGGTGACGAGTACAAACAC
TGGTTCCGGGTAAAATTTTTGCAGCAGTTCCGCTTGTTTTACCGTTGCAGTCAGGAGCACAAAACCATCATTATCGGTTG
GGTTAATGATTTCGATACGCTGCGCGCTTACGGCTCTAAAACGGATGCATATAAAGTGTTTGCGGAAATGCTGAAAGCAG
GTACTCCACCGGATGACTGGAACACACTACTCAACGCGGCAAAAAAAGCCACGGCCACAAACACTATTCCGGGTTTTCTC
ACTAGGCAACCCTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT199250 WP_032609984.1 NZ_CP072945:3722723-3723070 [Enterobacter sp. MGH 7]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT199250 NZ_CP097254:c12655-12311 [Enterobacter bugandensis]
ATGGCTACTCAAATTTTTCATAATGCGGACGTGTCCCTGCGCGCTGAGTCTCGACTCACCGAGCGCAGCCAGACAACGAT
TCCGGCAGCAATACGCGATGCATTGCATCTCAAGCCAGGTGAGTCCATTCACTATACCTTGCTTGCGGGCGGTAAAGTCA
TCATGTCTAAGAAGGAAGAAGAACAGGACGATCCGGTTATCCCACAGTTCCTGGCTTTTCTGGAAAACGACATGAAGAAA
AACCCTCAGAATATTGCCCCTGTTCCGGCTCTATTCTGGGAAAGCATCAAAGCTTTGACTGCTGGAGTTGAAGTTGATTT
AGACGCGCCGCTTACCGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References