Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4033928..4034463 Replicon chromosome
Accession NZ_CP072941
Organism Streptomyces yatensis strain DSM 41771

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag J8403_RS16400 Protein ID WP_211123835.1
Coordinates 4033928..4034182 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag J8403_RS16405 Protein ID WP_211123836.1
Coordinates 4034179..4034463 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8403_RS16380 4030096..4030569 + 474 WP_281427925.1 ATP-binding protein -
J8403_RS16385 4030626..4031510 + 885 WP_211123832.1 radical SAM protein -
J8403_RS16390 4031492..4032319 + 828 WP_246585862.1 phosphotransferase -
J8403_RS16395 4032438..4033934 + 1497 WP_211123834.1 M1 family metallopeptidase -
J8403_RS16400 4033928..4034182 - 255 WP_211123835.1 Txe/YoeB family addiction module toxin Toxin
J8403_RS16405 4034179..4034463 - 285 WP_211123836.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J8403_RS16410 4034578..4035465 - 888 WP_211123837.1 LysR family transcriptional regulator -
J8403_RS16415 4035536..4035853 + 318 WP_211123838.1 hypothetical protein -
J8403_RS16420 4035850..4036602 + 753 WP_211123839.1 SDR family oxidoreductase -
J8403_RS16425 4036766..4038097 + 1332 WP_211123840.1 MFS transporter -
J8403_RS16430 4038039..4038323 + 285 WP_246585863.1 amidohydrolase family protein -
J8403_RS16435 4038480..4039262 + 783 WP_211128723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4028635..4039262 10627


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-64)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10043.55 Da        Isoelectric Point: 7.2750

>T199235 WP_211123835.1 NZ_CP072941:c4034182-4033928 [Streptomyces yatensis]
VRLVFEDQGWEDYTSWLKNDRKMLARINRLIEDVKCDPFAGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIVILAA
RYHY

Download         Length: 255 bp

>T199235 NZ_CP097248:4680565-4681887 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTTACCGCCTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10174.39 Da        Isoelectric Point: 4.6652

>AT199235 WP_211123836.1 NZ_CP072941:c4034463-4034179 [Streptomyces yatensis]
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALDNINVSEREL
IDPDSPDAAGEGPA

Download         Length: 285 bp

>AT199235 NZ_CP097248:4680299-4680565 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References