Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 877123..877699 Replicon chromosome
Accession NZ_CP072934
Organism Corynebacterium pseudogenitalium strain CCUG 27540

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KBP54_RS04240 Protein ID WP_070976212.1
Coordinates 877123..877404 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KBP54_RS04245 Protein ID WP_070976454.1
Coordinates 877439..877699 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBP54_RS04235 (KBP54_04230) 876763..876993 - 231 WP_255366161.1 CopG family transcriptional regulator -
KBP54_RS04240 (KBP54_04235) 877123..877404 + 282 WP_070976212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KBP54_RS04245 (KBP54_04240) 877439..877699 + 261 WP_070976454.1 HigA family addiction module antitoxin Antitoxin
KBP54_RS04250 (KBP54_04245) 877754..878197 - 444 WP_070976455.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
KBP54_RS04255 (KBP54_04250) 878510..878674 - 165 WP_255366162.1 hypothetical protein -
KBP54_RS04260 (KBP54_04255) 878671..878907 - 237 WP_256006412.1 hypothetical protein -
KBP54_RS04265 (KBP54_04260) 879140..879634 - 495 WP_070976214.1 DUF1707 domain-containing protein -
KBP54_RS04270 (KBP54_04265) 879842..880459 + 618 WP_255366163.1 TipAS antibiotic-recognition domain-containing protein -
KBP54_RS04275 (KBP54_04270) 880896..881876 + 981 WP_070976216.1 NAD(P)-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-81)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11052.52 Da        Isoelectric Point: 9.0836

>T199231 WP_070976212.1 NZ_CP072934:877123-877404 [Corynebacterium pseudogenitalium]
MIQSFADKDTERLWNRERVRSIDSRIHSVALRKLRQLGYAQTLDELRIPPGNRLEALKGDRRGQFSIRIDDQWRICFRWS
AAGPEEVEIVDYH

Download         Length: 282 bp

>T199231 NZ_CP097248:2495168-2495515 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9643.25 Da        Isoelectric Point: 6.7238

>AT199231 WP_070976454.1 NZ_CP072934:877439-877699 [Corynebacterium pseudogenitalium]
MEDFLKEMGITQHKLAVSIGVPPRRINEIVHGKRAVTADTALRLAKFFGMSPQFWLGLQTQYDLDVAEDKILAEIERILP
VHAVSA

Download         Length: 261 bp

>AT199231 NZ_CP097248:2495515-2495814 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References