Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 862860..863294 Replicon chromosome
Accession NZ_CP072904
Organism Bartonella henselae strain Marseille/ URLLY-8

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag KAE73_RS03745 Protein ID WP_236093265.1
Coordinates 863169..863294 (+) Length 42 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag KAE73_RS03740 Protein ID WP_236093266.1
Coordinates 862860..863033 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAE73_RS03705 (KAE73_03600) 857954..858106 - 153 WP_011181195.1 DUF5993 family protein -
KAE73_RS03710 (KAE73_03605) 859079..859450 + 372 WP_082250432.1 helix-turn-helix transcriptional regulator -
KAE73_RS03715 (KAE73_03615) 860104..860517 + 414 WP_051524353.1 hypothetical protein -
KAE73_RS03720 (KAE73_03620) 860919..861164 + 246 WP_051524354.1 hypothetical protein -
KAE73_RS03725 (KAE73_03625) 861287..861460 - 174 WP_155265939.1 hypothetical protein -
KAE73_RS03730 (KAE73_03630) 861484..861828 - 345 WP_034454583.1 hypothetical protein -
KAE73_RS03735 (KAE73_03635) 862108..862476 + 369 WP_051401505.1 hypothetical protein -
KAE73_RS03740 (KAE73_03640) 862860..863033 + 174 WP_236093266.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KAE73_RS03745 863169..863294 + 126 WP_236093265.1 type II toxin-antitoxin system YafQ family toxin Toxin
KAE73_RS03750 (KAE73_03650) 863762..863986 - 225 WP_236095401.1 HigA family addiction module antitoxin -
KAE73_RS03755 864003..864125 - 123 Protein_723 type II toxin-antitoxin system RelE/ParE family toxin -
KAE73_RS03760 (KAE73_03660) 864525..864662 - 138 WP_155245675.1 hypothetical protein -
KAE73_RS03765 (KAE73_03665) 865394..865891 + 498 WP_011181203.1 5-(carboxyamino)imidazole ribonucleotide mutase -
KAE73_RS03770 (KAE73_03670) 865829..866161 - 333 WP_208432295.1 hypothetical protein -
KAE73_RS03775 (KAE73_03675) 866181..867251 + 1071 WP_236095402.1 5-(carboxyamino)imidazole ribonucleotide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-41)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-54)


Sequences

Toxin        


Download         Length: 42 a.a.        Molecular weight: 4945.51 Da        Isoelectric Point: 6.1907

>T199164 WP_236093265.1 NZ_CP072904:863169-863294 [Bartonella henselae]
MQGNWKPRCDLHREPDWLLIDSVNDEYVHCDRTGTHSNMFK

Download         Length: 126 bp

>T199164 NZ_CP097223:c1472286-1472184 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6742.71 Da        Isoelectric Point: 5.0190

>AT199164 WP_236093266.1 NZ_CP072904:862860-863033 [Bartonella henselae]
VSDFRGIAFTKVISEERLPFEMHIPNTETLKTFEKTDKGEDIFYAKDIKDFFKQLNI

Download         Length: 174 bp

>AT199164 NZ_CP097223:1472177-1472322 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References