Detailed information of TA system TA199151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1616392..1617019
• Replicon: chromosome
• Accession: NZ_CP072903
• Organism: Bartonella henselae strain ATCC49882T var-1/ Houston-I

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0H3M2H0
• Locus tag: KAE76_RS06760
• Protein ID: WP_011180277.1
• Coordinates: 1616392..1616706 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: KAE76_RS06765
• Protein ID: WP_011180278.1
• Coordinates: 1616723..1617019 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KAE76_RS06740 (KAE76_06635)	1612019..1613575	-	1557	WP_011180273.1	phage portal protein	-
KAE76_RS06745 (KAE76_06640)	1613575..1613823	-	249	WP_011180274.1	hypothetical protein	-
KAE76_RS06750 (KAE76_06645)	1613827..1615755	-	1929	WP_011180275.1	phage terminase large subunit family protein	-
KAE76_RS06755 (KAE76_06650)	1615748..1616329	-	582	WP_011180276.1	hypothetical protein	-
KAE76_RS06760 (KAE76_06655)	1616392..1616706	+	315	WP_011180277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KAE76_RS06765 (KAE76_06660)	1616723..1617019	+	297	WP_011180278.1	HigA family addiction module antitoxin	Antitoxin
KAE76_RS06770 (KAE76_06665)	1617429..1617692	+	264	WP_011180280.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
KAE76_RS06775 (KAE76_06670)	1617679..1617960	+	282	WP_011180281.1	type II toxin-antitoxin system YafQ family toxin	-
KAE76_RS06780 (KAE76_06675)	1618003..1618281	-	279	WP_011180242.1	hypothetical protein	-
KAE76_RS06785 (KAE76_06680)	1618278..1619036	-	759	WP_011180282.1	phage antirepressor Ant	-
KAE76_RS06790 (KAE76_06685)	1619096..1619611	-	516	WP_011180283.1	phage antirepressor Ant	-
KAE76_RS06795 (KAE76_06690)	1619628..1620467	-	840	WP_011180284.1	antA/AntB antirepressor family protein	-
KAE76_RS06800 (KAE76_06695)	1620499..1621041	-	543	WP_011180285.1	phage antirepressor Ant	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1572665..1642326	69661

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12135.97 Da
• Isoelectric Point: 9.0878

>T199151 WP_011180277.1 NZ_CP072903:1616392-1616706 [Bartonella henselae]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T199151 NZ_CP097220:389332-389649 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11262.91 Da
• Isoelectric Point: 5.8690

>AT199151 WP_011180278.1 NZ_CP072903:1616723-1617019 [Bartonella henselae]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSRITPDTALRLASFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Nucleotide

• Length: 297 bp

>AT199151 NZ_CP097220:389642-389929 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Toxin

• AlphaFold DB: A0A0H3M2H0